Cristin-prosjekt-ID: 2505747
Sist endret: 26. februar 2021, 22:45

Cristin-prosjekt-ID: 2505747
Sist endret: 26. februar 2021, 22:45
Prosjekt

REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)

prosjektleder

Svein Færestrand
ved Hjerteavdelingen ved Helse Bergen HF - Haukeland universitetssykehus

prosjekteier / koordinerende forskningsansvarlig enhet

  • Helse Bergen HF - Haukeland universitetssykehus

Klassifisering

Vitenskapsdisipliner

Andre klinisk medisinske fag

Emneord

Hjertestimulering, kunstig / Pacemakerbehandling

HRCS-helsekategori

  • Hjerte og kar

Kategorier

Prosjektkategori

  • Oppdragsprosjekt

Tidsramme

Avsluttet
Start: 1. juni 2006 Slutt: 27. mai 2012

Beskrivelse Beskrivelse

Tittel

REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)

Vitenskapelig sammendrag

The “REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction”
(REVERSE) study was a prospective, randomized, double-blind, multi-center global study
conducted in the United States, Canada and Europe. It was designed to determine whether
biventricular pacing limited the progression of heart failure in subject clinical status as compared
to optimal medical therapy alone in subjects with asymptomatic or mild heart failure (NYHA
Class I and II, Stage C), ventricular dyssynchrony (QRS ≥120 ms), and reduced systolic left
ventricular ejection fraction (LVEF ≤40%).
Enrolled subjects were implanted with a Medtronic CRT-P or CRT-D system (depending on ICD
indication), and following successful implant were randomized in a 2:1 fashion to one of two
study arms: biventricular pacing in conjunction with optimal medical therapy (CRT ON) or
optimal medical therapy alone (CRT OFF).
In the U.S. and Canada, subjects were unblinded at 12 months and continued to be seen annually
through 5 years of follow-up. European subjects were unblinded at 24 months and were seen
annually thereafter until 5 years. It was recommended that all subjects have CRT programmed on
at the conclusion of the blinded follow-up.
The intent of the study was to show that the CRT ON group had more limited disease
progression as compared to the CRT OFF group. In addition, reverse remodeling was assessed
by comparing the change in left ventricular end systolic volume index (LVESVi) from baseline
to 12 months between the CRT ON group and the CRT OFF group.

prosjektdeltakere

prosjektleder

Svein Færestrand

  • Tilknyttet:
    Prosjektleder
    ved Hjerteavdelingen ved Helse Bergen HF - Haukeland universitetssykehus

Gaute Vollan

  • Tilknyttet:
    Prosjektdeltaker
    ved Hjerteavdelingen ved Helse Bergen HF - Haukeland universitetssykehus

Thomas Hovstad

  • Tilknyttet:
    Prosjektdeltaker
    ved Hjerteavdelingen ved Helse Bergen HF - Haukeland universitetssykehus
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Resultater Resultater

The Impact of the PR Interval in Patients Receiving Cardiac Resynchronization Therapy.

Authors, Investigators; Færestrand, Svein. 2017, JACC: Clinical Electrophysiology. UIBVitenskapelig artikkel

Baseline characteristics of patients randomised in REsynchronization reverses Remodeling in Systolic left vEntricular dysfunction (REVERSE) study.

Authors, Investigators; Færestrand, Svein. 2008, Congestive Heart Failure: Disease State Management Resource. UIBVitenskapelig artikkel
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