Cristin-prosjekt-ID: 2510274
Sist endret: 7. mai 2021, 15:30

Cristin-prosjekt-ID: 2510274
Sist endret: 7. mai 2021, 15:30
Prosjekt

Novel transferable non-beta-lactam resistance in Haemophilus influenzae

prosjektleder

Helene Johannessen
ved Klinikk Med Diagnostikk ved Sykehuset i Vestfold HF

prosjekteier / koordinerende forskningsansvarlig enhet

  • Sykehuset i Vestfold HF

Klassifisering

Vitenskapsdisipliner

Bioinformatikk • Medisinsk molekylærbiologi • Medisinsk mikrobiologi • Generell mikrobiologi

Emneord

Antibiotikaresistens • Medisinsk mikrobiologi • Mikrobiologi • Antibiotika • Antibiotika resistens

HRCS-helsekategori

  • Lunger og luftveier
  • Infeksjon
  • Generell helserelevans

HRCS-forskningsaktivitet

  • 1.1 Normal biologisk utvikling og funksjon
  • 2.1 Biologiske og indre faktorer

Kategorier

Prosjektkategori

  • Grunnforskning

Kontaktinformasjon

Telefon
97960181
Sted
Helene Johannessen

Tidsramme

Avsluttet
Start: 1. august 2020 Slutt: 31. juli 2021

Beskrivelse Beskrivelse

Tittel

Novel transferable non-beta-lactam resistance in Haemophilus influenzae

Vitenskapelig sammendrag

Resistance to antibiotics is an emerging threat to global health care, and immediate action is necessary to preserve effective antibiotics for the future. One of the major objectives of the Norwegian national strategy to fight antibiotic resistance is to increase our knowledge about drivers and mechanisms of evolution and spread of antibiotic resistance. Dissemination of Haemophilus influenzae with multidrug-resistance (MDR) represents a threat to current empiric therapy. Investigations have shown that such strains are increasingly frequent. The extent and mechanisms of MDR in H. influenzae is incompletely understood, and more research is needed to elucidate resistance development at a molecular level.


Our research group has a unique collection of 224 strains of Norwegian H. influenzae with high-level beta-lactam resistance. These strains have been characterized using state-of-the-art methods, and preliminary investigations have revealed several strains possessing transferable genes conferring resistance to a wide range of antibiotics, including genes that are rare or previously undescribed. In this study, we will describe the genetic environment, mechanisms of transfer, impact on phenotypic susceptibility, and fitness cost of novel or rare transferable non-beta-lactam resistance genes in MDR-strains of H. influenzae. Such identification and characterizing is an important step to identify intervention strategies to prevent development and spread of MDR H. influenzae.

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Helene Johannessen

  • Tilknyttet:
    Prosjektleder
    ved Klinikk Med Diagnostikk ved Sykehuset i Vestfold HF

Dagfinn Skaare

  • Tilknyttet:
    Prosjektdeltaker
    ved Klinikk Med Diagnostikk ved Sykehuset i Vestfold HF
1 - 2 av 2