Cristin-prosjekt-ID: 2516989
Sist endret: 6. september 2021, 14:34

Cristin-prosjekt-ID: 2516989
Sist endret: 6. september 2021, 14:34
Prosjekt

Exploring the Causal Effects of Immune Responses to Cognitive and Mental Health - Integrating Large-scale Genomics with Longitudinal Studies

prosjektleder

Yunpeng Wang
ved Psykologisk institutt ved Universitetet i Oslo

prosjekteier / koordinerende forskningsansvarlig enhet

  • Psykologisk institutt ved Universitetet i Oslo

Klassifisering

Vitenskapsdisipliner

Medisinsk genetikk

HRCS-helsekategori

  • Mental helse

Kategorier

Prosjektkategori

  • Faglig utviklingsarbeid

Tidsramme

Aktivt
Start: 1. april 2020 Slutt: 31. mars 2024

Beskrivelse Beskrivelse

Tittel

Exploring the Causal Effects of Immune Responses to Cognitive and Mental Health - Integrating Large-scale Genomics with Longitudinal Studies

Vitenskapelig sammendrag

The immune system and the brain are arguably the two major adaptive systems in the body, and, they communicate with each other extensivelyto cope with physiological and external changes. Abnormalities in such communications underlie many neuropsychiatric and neurodegenerative diseases, such as schizophrenia, autism spectral disorders, depression, Alzheimer's and Parkinson's diseases. Hence, properly controlled immune responses to inflammation and antigens are important for brain, cognitive and mental health. Cytokines are key components in the immune system, and function as signaling molecules for communications among cells, tissues and organs. In this project, we will study the effects of circulating levels of several cytokines on brain, cognitive and mental health. We will go beyond statistical correlations by estimating the causal effects of cytokine levels on brain structural changes and cognitive performance. To achieve our goal,

we will integrate the unprecedented statistical power of large-scale genomic data with fine-grained longitudinal samples. In addition, we will investigate whether the effects of cytokine on brain, cognitive and mental health varies with age, sex and environmental factors. Leveraging on the state-of-the-art methodologies and big data, this project will contribute to our knowledge on the relations between immune responses and brain, cognitive and mental health.

prosjektdeltakere

prosjektleder

Yunpeng Wang

  • Tilknyttet:
    Prosjektleder
    ved Psykologisk institutt ved Universitetet i Oslo
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Resultater Resultater

Gut microbial biomarkers for the treatment response in first-episode, drug-naïve schizophrenia: a 24-week follow-up study.

Yuan, Xiuxia; Wang, Yunpeng; Li, Xue; Jiang, Jiajun; Kang, Yulin; Pang, Lijuan; Zhang, Peifen; Li, Ang; Lv, Luxian; Andreassen, Ole mfl.. 2021, Translational Psychiatry. KINA, CRAES, UMASS, UIO, ZU, OUSVitenskapelig artikkel

Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction.

Sun, Jiangming; Wang, Yunpeng; Folkersen, Lasse; Borne, Yan; Amlien, Inge; Buil, Alfonso; Orho-Melander, Marju; Borglum, Anders D; Hougaard, David; Melander, Olle mfl.. 2021, Nature Communications. AU, LUNDBECK, SSI, Lu, UIO, ITU, MGH, DANMARKVitenskapelig artikkel

Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness.

Cheng, Weiqiu; Frei, Oleksandr; van der Meer, Dennis; Wang, Yunpeng; O`Connell, Kevin; Chu, Yunhan; Bahrami, Shahram; Shadrin, Alexey A.; Alnæs, Dag; Hindley, Guy Frederick Lanyon mfl.. 2021, JAMA psychiatry. KCLUOL, DIAKONSYK, UM, UCSD, UIO, OUS, UIB, ETVitenskapelig artikkel

Insulin Resistance and Oxidative Stress: In Relation to Cognitive Function and Psychopathology in Drug-Naïve, First-Episode Drug-Free Schizophrenia.

Tao, Qi; Miao, Yun; Li, Huihui; Yuan, Xiuxia; Huang, Xufeng; Wang, Yunpeng; Andreassen, Ole Andreas; Fan, Xiaoduo; Yang, Yongfeng; Song, Xueqin. 2020, Frontiers in Psychiatry. UMASS, UIO, ZU, UOW, XMCVitenskapelig artikkel

Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan.

Walhovd, Kristine B; Fjell, Anders Martin; Sørensen, Øystein; Mowinckel, Athanasia Monika; Reinbold, Céline Sonja; Idland, Ane-Victoria; Watne, Leiv; Franke, Andre; Dobricic, Valerija; Kilpert, Fabian mfl.. 2020, Neurology: Genetics. UNILUEBECK, CAU, UIO, OUSVitenskapelig artikkel
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