Cristin-prosjekt-ID: 2524169
Sist endret: 16. august 2023, 09:45

Cristin-prosjekt-ID: 2524169
Sist endret: 16. august 2023, 09:45
Prosjekt

CORNELIA: AMR in One Health Interfaces

prosjektleder

Yngvild Wasteson
ved Veterinærhøgskolen ved Norges miljø- og biovitenskapelige universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Veterinærhøgskolen ved Norges miljø- og biovitenskapelige universitet

Klassifisering

Vitenskapsdisipliner

Miljøteknologi • Infeksjonsmedisin • Medisinsk mikrobiologi

Emneord

Avløpsvann • Én helse • Antimikrobiell resistens

HRCS-helsekategori

  • Generell helserelevans

HRCS-forskningsaktivitet

  • 1.4 Metodologi og målinger

Kategorier

Prosjektkategori

  • Anvendt forskning

Tidsramme

Aktivt
Start: 1. mai 2021 Slutt: 31. juli 2024

Beskrivelse Beskrivelse

Tittel

CORNELIA: AMR in One Health Interfaces

Populærvitenskapelig sammendrag

The One Health concept acknowledges the interconnectedness of human, animal and environmental health. In order to study the interaction between humans, animals, and the environment and how this affects the spread of infectious agents and antimicrobial resistance (AMR), cross-sectoral and transdisciplinary cooperation is key. In CORNELIA, we have put together researchers from all three One Health pillars, including groups representing biological and technological sectors.

AMR is one of the greatest health threats of our time, challenging both human and veterinary medicine. The use of antimicrobial agents is the main driver of the development and spread of resistance. Identical AMR determinants and their corresponding genetic vehicles occur in bacteria isolated from humans, animals, and the environment. In CORNELIA we will study how the development and dissemination of AMR take place between bacteria that belong to humans, animals and the environment. Our research questions are based on the fact that wastewater, sludge and manure constitute a melting pot for interactions between such different bacteria. These interfaces are well suited for the selection and spread of new resistance determinants, which will be transferred to soil and water and potentially recycled into the food chains.  CORNELIA will assess the consequences this may have for public and animal health.

The consortium will develop a scientific basis and strategies for a potential national monitoring program for AMR in the environment, as a parallel to the existing surveillance programs in humans, animals, and food. We are also working with two start-up companies to test innovative solutions to reduce the amount of AMR that is released into the environment from treatment plants, using VEAS and OUS as our experimental sites.

The project is a collaboration between NMBU, UiT, FHI, NIBIO, NIVA, OUS, VEAS, Blueshift and Sustaintech.

Vitenskapelig sammendrag

The One Health perspective is based on an understanding that human, animal and ecosystem health are inextricablylinked. As antimicrobial resistance (AMR) exists in and affects all sectors, a One Health approach is required toaddress the dynamic and cross-sectorial behavior of the current AMR-threat. Environmental compartments as waterand soil are dynamic and complex compartments representing important interfaces for all One Health sectors butare yet the most neglected part of One Health-AMR initiatives. The CORNELIA project (Antimicrobial Resistance inOne Health Interfaces) challenges the environmental knowledge gap, and addresses development and disseminationof AMR in soil and aquatic environments as they are important interfaces between humans and animals. We do thiswith an interdisciplinary and cross-sectorial approach, involving participation from all the three pillars of One Healthand bringing the biology and technology sectors together in exploiting new technologies for data analysis andsurveillance, development of diagnostic tools and establishment of mitigation measures.CORNELIA is organized into five scientific workpackages, and each workpackage is designed to fill in knowledge gapsdescribed in previous research and risk assessments: 1) Occurrence of AMR in environmental interfaces, 2) Newdiagnostic tools and new technologies for diagnosis and metagenome and whole genome sequence data, 3)Persistence, transmission and expression of AMR in environmental interfaces, 4) Strategies for surveillance of AMR inthe environment, 5) Innovative technologies for AMR mitigation and wastewater treatment.The comprehensive CORNELIA team consists of scientific partners from NMBU, FHI, UiT, NIBIO, and NIVA, and twostart-up companies within wastewater technology; Blueshift AS and Sustaintech AS. Access to relevant sampling andtesting of technology are ensured through collaboration with OUS and VEAS.

Metode

Analysis of wastewater and environmental samples; microbiology and technology

Utstyr

Laboratory infratsructures and pilot equipment for removal of bacteria at the WWTP and at OUS

prosjektdeltakere

prosjektleder

Yngvild Wasteson

  • Tilknyttet:
    Prosjektleder
    ved Veterinærhøgskolen ved Norges miljø- og biovitenskapelige universitet

Adriana Dorota Osinska

  • Tilknyttet:
    Prosjektdeltaker
    ved Norges miljø- og biovitenskapelige universitet

Rune Holmstad

  • Tilknyttet:
    Prosjektdeltaker
    ved Vestfjorden Avløpsselskap

Nina Due

  • Tilknyttet:
    Prosjektdeltaker
    ved Oslo universitetssykehus HF

Pawel Konrad Krzeminski

  • Tilknyttet:
    Prosjektdeltaker
    ved Norsk institutt for vannforskning
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Resultater Resultater

Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs?

Bengtsson-Palme, Johan; Abramova, Anna; Berendonk, Thomas U.; Coelho, Luis Pedro; Forslund, Sofia K.; Gschwind, Remi; Heikinheimo, Annamari; Jarquin-Diaz, Victor Hugo; Khan, Ayaz Ali; Klümper, Uli mfl.. 2023, Environment International. FFA, TUD, QUI, UPARIS, FUS, FHI, LÄKEMEDEL, Gu, SA, UPN(X, UOM, EMBL, GER, HY-HU, Cth, NMBU, THL, CHARITE, HELMVitenskapelig oversiktsartikkel/review

The occurrence of beta-lactams resistant Escherichia coli in wastewater samples.

Osinska, Adriana Dorota; Lindstedt, Bjørn-Arne; Mekonnen, Yohannes Beyene; Sørum, Henning; Wasteson, Yngvild. 2022, Environmental Dimensions of Antimicrobial Resistance. NMBU, AHUSPoster

Bidrar avløpsvann til spredning av resistente bakterier og antibiotika i Oslofjorden?

Wasteson, Yngvild. 2022, Seminar forskningsdagene 2022. NMBUFaglig foredrag

Trenger vi ny teknologi for å redusere utslippet av resistente bakterier i miljøet?

Wasteson, Yngvild. 2022, Frokostseminar om En helse og AMR. NMBUFaglig foredrag

CORNELIA: AMR in One Health Interfaces.

Wasteson, Yngvild. 2021, AMR - Nordic One Health seminar. NMBUVitenskapelig foredrag
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