Cristin-prosjekt-ID: 2536831
Sist endret: 28. mars 2022, 16:54

Cristin-prosjekt-ID: 2536831
Sist endret: 28. mars 2022, 16:54
Prosjekt

Exploring the progression of mental illness: Identifying predictors of recovery

prosjektleder

Robyn Wootton
ved Lovisenberg Diakonale Sykehus

prosjekteier / koordinerende forskningsansvarlig enhet

  • Nic Waals Institutt ved Lovisenberg Diakonale Sykehus

Finansiering

  • TotalbudsjettNOK 3.000.000
  • Helse Sør-Øst RHF
    Prosjektkode: 2020024

Klassifisering

Vitenskapsdisipliner

Epidemiologi medisinsk og odontologisk statistikk

Emneord

Fødselsdepresjon • Recovery • Longitudinelle studier • Depresjon • Kausal inferens • Epidemiologi

HRCS-helsekategori

  • Mental helse

HRCS-forskningsaktivitet

  • 2 Årsaksforhold

Kategorier

Prosjektkategori

  • Bidragsprosjekt

Kontaktinformasjon

Sted
Robyn Wootton

Tidsramme

Aktivt
Start: 20. november 2020 Slutt: 19. november 2023

Beskrivelse Beskrivelse

Tittel

Exploring the progression of mental illness: Identifying predictors of recovery

Populærvitenskapelig sammendrag

Depression is the leading cause of global disability with over 300 million people suffering worldwide. Estimates suggest that up to two thirds of patients do not recover following their first antidepressant treatment and up to one third do not recover after multiple treatments. Therefore, it is critically important to identify factors that predict recovery and reduce risk of relapse. Current methods in genetic epidemiology focus on predictors of mental illness onset. While this is crucial to prevent new diagnoses, it does little to help individuals already suffering. Therefore, the Recover project aims to extend current genetic epidemiology methods to better understand recovery from depression. The methods developed here will begin with a focus on depression but can also be extended to other mental illnesses. First, we will develop trajectories of depression using continuous longitudinal measures in two critical time points, 1) adolescence and early adulthood and 2) during and post pregnancy. Second, using these trajectories as outcomes we will explore many modifiable predictors of recovery. Third, we will use cutting-edge causal inference techniques to test whether or not these predictors are causal. And finally, we will develop novel technologies to capture fine-grained fluctuations in mood. Taken together, this work will lead to better interventions and inform adjuncts to treatment having real impact for the growing number of individuals suffering from depression.

Metode

The primary aim of the Recover project is to extend current genetic epidemiology methods to better understand recovery from depression. This will be achieved through four secondary aims: 1: Develop trajectories of depression - using detailed longitudinal measures of symptom severity. 2: Identify factors that predict recovery – using a wealth of cohort data available to test previously hypothesised as well as novel predictors. 3: Test whether the predictors are causal – using causal inference techniques and cutting-edge methods to adjust for additional sources of bias. 4. Measure mood variability – using ecological momentary assessment to capture fine-grained fluctuations and pioneer this approach for use in cohort studies.

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Robyn Wootton

  • Tilknyttet:
    Prosjektleder
    ved Lovisenberg Diakonale Sykehus
Aktiv cristin-person

Alexandra Havdahl

  • Tilknyttet:
    Lokalt ansvarlig
    ved Avdeling for psykiske lidelser ved Folkehelseinstituttet
  • Tilknyttet:
    Lokalt ansvarlig
    ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus
  • Tilknyttet:
    Lokalt ansvarlig
    ved Helse-, utviklings- og personlighetspsyk ved Universitetet i Oslo
Aktiv cristin-person

Anne-Siri Øyen

  • Tilknyttet:
    Prosjektdeltaker
    ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus

Andrew Skinner

  • Tilknyttet:
    Prosjektdeltaker
    ved University of Bristol

Marcus R. Munafò

  • Tilknyttet:
    Prosjektdeltaker
    ved University of Bristol
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Resultater Resultater

Mendelian randomisation for psychiatry: how does it work, and what can it tell us?

Wootton, Robyn; Jones, Hannah J.; Sallis, Hannah M.. 2021, Molecular Psychiatry. NHS, UoB, LDSVitenskapelig oversiktsartikkel/review
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