Cristin-prosjekt-ID: 2536845
Sist endret: 29. mars 2022, 17:40

Cristin-prosjekt-ID: 2536845
Sist endret: 29. mars 2022, 17:40
Prosjekt

Examining long-term trajectories and outcomes of children at genetic risk for neurodevelopmental disorders (EXTEND)

prosjektleder

Alexandra Havdahl
ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus

prosjekteier / koordinerende forskningsansvarlig enhet

  • Nic Waals Institutt ved Lovisenberg Diakonale Sykehus

Finansiering

  • TotalbudsjettNOK 3.561.000
  • Helse Sør-Øst RHF
    Prosjektkode: 2022029

Klassifisering

Vitenskapsdisipliner

Genetikk og genomikk • Epidemiologi medisinsk og odontologisk statistikk • Psykologi

Emneord

Nevroutviklingsforstyrrelser

Kategorier

Prosjektkategori

  • Doktorgradsprosjekt

Tidsramme

Aktivt
Start: 1. juni 2022 Slutt: 31. desember 2025

Beskrivelse Beskrivelse

Tittel

Examining long-term trajectories and outcomes of children at genetic risk for neurodevelopmental disorders (EXTEND)

Vitenskapelig sammendrag

Neurodevelopmental problems are frequently occurring in children from an early age and around one in ten are eventually diagnosed with a neurodevelopmental disorder, such as autism or ADHD. These problems and disorders are associated with often life-long impairments and distress for individuals and families, and high societal costs. Still, there is a wide gap in knowledge of the long-term course and outcomes of children at risk. Bringing together state-of-the-art molecular genetic and epidemiological methods and unique long-term longitudinal data from the Norwegian Mother, Father and Child Cohort (MoBa, N>100,000 pregnancies), the EXTEND project will provide clinically actionable insights and an empirical platform for better understanding how genetic liabilities for neurodevelopmental disorders manifest in boys and girls across early childhood, adolescence and early adulthood. Access to genome-wide association discovery samples of unprecedented sample sizes, with up to five times more cases of neurodevelopmental disorders as previously available, allows us to calculate the individual genetic risk for in MoBa participants with increased precision. The rich and longitudinal follow-up data will allow us to identify environmental factors that reduce adverse phenotypic expressions of the genetic risk. Knowledge of sex differences, developmental patterns, and protective factors will aid early detection, identification of intervention targets and optimal timing of interventions.

Metode

EXTEND will use PGSs to index genetic risk, given these are well-established as biologically valid indices of genetic liability. Using MoBa as target sample, including the now available genotype data on more than 80,000 children with long-term follow-up data, EXTEND has unique opportunities to advance knowledge on long-term manifestations of genetic risk for neurodevelopmental disorders.

prosjektdeltakere

prosjektleder

Alexandra Havdahl

  • Tilknyttet:
    Prosjektleder
    ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus
  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Stian Barbo Valand

  • Tilknyttet:
    Prosjektdeltaker
    ved Lovisenberg Distriktspsykiatriske Senter ved Lovisenberg Diakonale Sykehus
Aktiv cristin-person

Helga Ask

  • Tilknyttet:
    Prosjektdeltaker
    ved Helse-, utviklings- og personlighetspsyk ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved Avdeling for psykiske lidelser ved Folkehelseinstituttet

Somer L Bishop

  • Tilknyttet:
    Prosjektdeltaker
    ved University of San Francisco

George Davey-Smith

  • Tilknyttet:
    Prosjektdeltaker
    ved University of Bristol
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