Cristin-prosjekt-ID: 2539874
Sist endret: 27. mai 2022, 15:15

Cristin-prosjekt-ID: 2539874
Sist endret: 27. mai 2022, 15:15
Prosjekt

Morbid obesity and bariatric surgery – minerals, micronutrients and health

prosjektleder

Jan Olav Aaseth
ved Forskning og innovasjon ved Sykehuset Innlandet HF

prosjekteier / koordinerende forskningsansvarlig enhet

  • Sykehuset Innlandet HF

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Prosjektkategori

  • Doktorgradsprosjekt

Kontaktinformasjon

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Avsluttet
Start: 26. mars 2015 Slutt: 1. juni 2021

Beskrivelse Beskrivelse

Tittel

Morbid obesity and bariatric surgery – minerals, micronutrients and health

Vitenskapelig sammendrag

Part of  the Morbid Obesity – Bio-Psycho-Social study based at  Sykehuset Innlandet, Norway.  PhD candidate Solveig Meyer Mikalsen

There is a globally  increasing prevalence of obesity which predisposes to comorbidities like type 2 diabetes, hypertension, dyslipidemia and coronary heart disease. As weight loss is associated with improvement in metabolic function an increasing number of patients are referred to bariatric surgery. About 80% of  patients undergoing bariatric surgery are women, many in their childbearing age.

Serum magnesium (Mg) is reported to be reduced in individuals with obesity , diabetes, and hypertension  and has been suggested as a marker and possible pathogenic factor in the development of  metabolic syndrome .

We studied changes in serum Mg concentrations in obese patients  who underwent lifestyle interventions followed by Roux-en-Y gastric bypass (RYGB) during a period of 14 months and found that a modest weight loss of approximately 10 kg after > 8 weeks of lifestyle interventions increased serum Mg by about 5%. After surgery serum Mg remained stable  in  nondiabetic patients, while it continued to increase in  diabetic patients.

As even small increments in serum Mg are reported to lower the risk of cardiovascular and ischemic heart disease, our results are interesting in a public health perspective.

Weight loss is associated with improved fertility rates  but bariatric surgery is also regarded as a risk factor for adverse pregnancy outcomes , particularly due to disturbances in micronutrient status . Exposure to toxic elements during fetal life and infancy may have serious long-term health consequences for the child, and cause damage to the central nervous system, lungs and kidneys.

We studied changes in whole blood Hg, Pb and Cd concentrations before and 12 months after RYGB in a group of patients with a BMI≥35, where the majority  were women of reproductive age.  We found that weight loss induced by bariatric surgery increased median whole blood Pb significantly, whereas it reduced Hg and Cd concentrations as measured one year after surgery. Weight loss is known to increase fertility, and as the majority of bariatric surgery patients are women of reproductive age,  increase in whole blood Pb concentrations is of concern. Further studies should be performed in this field.

Improved Magnesium Levels in Morbidly Obese Diabetic and Non-diabetic Patients After Modest Weight Loss.

prosjektdeltakere

prosjektleder

Jan Olav Aaseth

  • Tilknyttet:
    Prosjektleder
    ved Forskning og innovasjon ved Sykehuset Innlandet HF

Solveig Meyer Mikalsen

  • Tilknyttet:
    Prosjektdeltaker
    ved Div Medisinsk service ved Sykehuset Innlandet HF
  • Tilknyttet:
    Prosjektdeltaker
    ved Universitetet i Bergen

Jon Elling Whist

  • Tilknyttet:
    Prosjektdeltaker
    ved Div Medisinsk service ved Sykehuset Innlandet HF

Anne-Lise Bjørke Monsen

  • Tilknyttet:
    Prosjektdeltaker
    ved Universitetet i Bergen
  • Tilknyttet:
    Prosjektdeltaker
    ved Laboratorium for klinisk biokjemi ved Helse Bergen HF - Haukeland universitetssykehus
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Resultater Resultater

Essential trace elements in Norwegian obese patients before and 12 months after Roux-en-Y gastric bypass surgery: Copper, manganese, selenium and zinc.

Mikalsen, Solveig Meyer; Aaseth, Jan; Flaten, Trond Peder; Whist, Jon Elling; Monsen, Anne Lise Bjørke. 2020, Journal of Trace Elements in Medicine and Biology. NTNU, HAUKELAND, INNLANDET, UIBVitenskapelig artikkel

Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery.

Mikalsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan. 2019, Journal of Trace Elements in Medicine and Biology. HINN, HAUKELAND, NTNU, INNLANDET, UIBVitenskapelig artikkel

Improved magnesium levels in morbidly obese diabetic and non-diabetic patients after modest weight loss.

Mikaelsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Whist, Jon Elling; Aaseth, Jan. 2018, Biological Trace Element Research. HINN, HAUKELAND, INNLANDET, UIBVitenskapelig artikkel
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