Cristin-prosjekt-ID: 316445
Sist endret: 15. januar 2015, 20:02

Cristin-prosjekt-ID: 316445
Sist endret: 15. januar 2015, 20:02
Prosjekt

The relative importance of neural and mechanical stimuli in skeletal muscle in rat.

prosjektleder

Einar Eftestøl
ved Det matematisk-naturvitenskapelige fakultet ved Universitetet i Oslo

prosjekteier / koordinerende forskningsansvarlig enhet

  • Universitetet i Oslo

Tidsramme

Avsluttet
Start: 1. januar 2010 Slutt: 1. september 2013

Beskrivelse Beskrivelse

Tittel

The relative importance of neural and mechanical stimuli in skeletal muscle in rat.

Sammendrag

When doing strength training, the muscle cells are activated upon demand through neurons. As the weight lifted increases, the neural activity progressively increases, activating each muscle cell to work harder, and activating more muscle cells. As you do strength training over time, you will normally increase muscle size (hypertrophy). The mechanisms underlying this hypertrophy are not well known, and whether it is the neural input activating the muscles, or the (bio)mechanical loading that results, or the two combined that activates this hypertrophy pathway is not known. This needs to be addressed in relation to sports and training mathods, but also in relation to diseases like type 2 diabetes, that is tightly linked to muscle. Recovery after a spinal cord injury is also linked to this research.

Vitenskapelig sammendrag

When doing strength training, the muscle cells are activated upon demand through neurons. As the weight lifted increases, the neural activity progressively increases, activating each muscle cell to work harder, and activating more muscle cells. As you do strength training over time, you will normally increase muscle size (hypertrophy). The mechanisms underlying this hypertrophy are not well known, and whether it is the neural input activating the muscles, or the (bio)mechanical loading that results, or the two combined that activates this hypertrophy pathway is not known. This needs to be addressed in relation to sports and training mathods, but also in relation to diseases like type 2 diabetes, that is tightly linked to muscle. Recovery after a spinal cord injury is also linked to this research.

Metode

To address the question of the relative importance of the neural input and the mechanical load put on skeletal muscle, we have used a method that separates these two stimuli, so that these can be manipulated separately. For this, we use an in vivo training machine, hereby called a myograph, where the electrical input and the mechanical loading on the muscles is regulated and registered in a highly specific manner. All training sessions is performed with sedated rats, so that no interference with the stimulation pattern or mechanical loading can take place. We then need to set up different strength training regimes that leads to hypertrophy, and compare the relative effect of the different regimes on hypertrophy.

Utstyr

Muscle stimulation and force registration system = myograph.
http://www.aurorascientific.com/

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Einar Eftestøl

  • Tilknyttet:
    Prosjektleder
    ved Det matematisk-naturvitenskapelige fakultet ved Universitetet i Oslo
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