Cristin-prosjekt-ID: 352006
Sist endret: 22. oktober 2015, 10:06

Cristin-prosjekt-ID: 352006
Sist endret: 22. oktober 2015, 10:06
Prosjekt

Co-occurrence of IBS and depression and anxiety among Norwegian twins

prosjektleder

May-Bente Bengtson
ved Medisinsk klinikk ved Sykehuset i Vestfold HF

prosjekteier / koordinerende forskningsansvarlig enhet

  • Medisinsk klinikk ved Sykehuset i Vestfold HF
  • Folkehelseinstituttet

Klassifisering

Vitenskapsdisipliner

Basale medisinske, odontologiske og veterinærmedisinske fag

Emneord

irritabel tarmsyndrom • Depresjon • Tvillinger • Lav fødselsvekt • Angst

HRCS-helsekategori

  • Mental helse

HRCS-forskningsaktivitet

  • 1.1 Normal biologisk utvikling og funksjon

Kategorier

Prosjektkategori

  • Grunnforskning

Kontaktinformasjon

Telefon
93236365
Sted
May-Bente Bengtson

Tidsramme

Avsluttet
Start: 1. juli 2011 Slutt: 31. desember 2013

Beskrivelse Beskrivelse

Tittel

Co-occurrence of IBS and depression and anxiety among Norwegian twins

Sammendrag

Background and aims: Environmental and genetic factors contribute to variation in IBS, depression and anxiety. Comorbidity between these disorders is high. A previous investigation of our population-based twin cohort revealed that low birth weight increased the risk for development of IBS, with environmental influences in utero as the most relevant contributing factor. We hypothesise that both intrauterine and genetic factors influence the co-occurrence of IBS and psychiatric characteristics.

Vitenskapelig sammendrag

Background and aims: Environmental and genetic factors contribute to variation in IBS, depression and anxiety. Comorbidity between these disorders is high. A previous investigation of our population-based twin cohort revealed that low birth weight increased the risk for development of IBS, with environmental influences in utero as the most relevant contributing factor. We hypothesise that both intrauterine and genetic factors influence the co-occurrence of IBS and psychiatric characteristics.

Metode

Methods: A postal questionnaire, sent in 1998, to 12700 Norwegian twins born between 1967 and 1979, based on the Norwegian national birth registry, established in 1967, included a checklist of 31 illnesses and symptoms, including IBS, 2 items on anxiety and 3 items on depression. This short form questionnaire of psychometric characteristics has been shown to correlate 0.85 with the full scale checklist of Hopkins (HSCL-25) anxiety and depression score. The co-occurrence of IBS and symptoms of anxiety and depression were tested in the full sample and adjusted for sex. The results from this analysis were then compared to those based on monozygotic (MZ) twin pairs discordant for IBS (297 pairs) to control for genetic factors. Furthermore, to explore whether the co-occurrence of IBS with symptoms of anxiety and depression could be caused by common intrauterine environmental factors analyses were conducted based on stratifying the data from IBS discordant MZ pairs into two birth weight groups, below and above 2500 g. Paired t-tests were performed using data from MZ pairs discordant for anxiety (109 pairs) and depression (155 pairs), respectively, to analyse the influence of restricted birth weight on the development of these symptoms. Results: The analysis of the full sample revealed that IBS was significantly associated with depression (OR = 2.5. 95 % CI: 1.9, 3.3) and anxiety (OR = 2.8, 95 % CI: 2.0, 3.8). Analyses of MZ pairs discordant for IBS indicated significant associations between IBS and depression (OR = 4.0, 95 % CI: 1.2, 13.7), and between IBS and anxiety (OR = 6.6, 95 % CI: 1.3, 32.8) only in the birth weight group below 2500 g. The t-test results indicated that among the MZ twins with birth weight below 2500 g the twins with depression (193.9 g, p < 0.001) and anxiety (178.4 g, p = 0.006) were significantly lighter than their control co-twins. Conclusion: This study suggests that genetic factors could partly explain the association between the disorders IBS, anxiety and depression, in normal range of birth weight (> 2500 g). In the low range of birth weight scale (< 2500 g), restricted fetal growth seems to be a common contributing factor to the development of these disorders as well as to the co-occurrence between them.

prosjektdeltakere

prosjektleder

May-Bente Bengtson

  • Tilknyttet:
    Prosjektleder
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF
Aktiv cristin-person

Geir Aamodt

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for folkehelsevitenskap ved Norges miljø- og biovitenskapelige universitet

Jennifer R. Harris

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet
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Resultater Resultater

Co-occurrence of IBS and symptoms of anxiety or depression, among Norwegian twins, is influenced by both heredity and intrauterine growth.

Bengtson, May-Bente; Aamodt, Geir; Vatn, Morten H; Harris, Jennifer. 2015, BMC Gastroenterology. FHI, NMBU, VESTFOLD, UIO, AHUSVitenskapelig artikkel
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