Vitenskapelig sammendrag
Research project to strengthen genetic-epidemiological research in the Helse Sør-Øst region, through collaboration between the Morbid Obesity Center at Vestfold Hospital Trust and Section for Medical Genetics at Telemark Hospital Trust.
Metode
In this project, the overall aim is to establish a research design including a gene-panel to investigate genotype-phenotype relations between candidate genes, morbid obesity, diabetes and other obesity-related traits using DNA and extensive clinical information from the Morbid Obesity Registry and Biobank Study at the Morbid Obesity Center at Vestfold Hospital Trust. By evaluating past and current findings based on GWA studies, we seek to validate and expand the results, and thus to contribute to the continuing exploration and dissection of the complex genetic background of obesity, diabetes and related phenotypes. The ultimate aims are to gain new knowledge about disease mechanisms and to improve clinical investigations and risk assessment, which may over time facilitate the possibilities for targeted prevention and treatment of obesity and related conditions.
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