Cristin-prosjekt-ID: 411181
Sist endret: 27. oktober 2015, 07:57

Cristin-prosjekt-ID: 411181
Sist endret: 27. oktober 2015, 07:57
Prosjekt

3 dimensional echocardiography in severity grading of aortic stenosis and coronary heart disease

prosjektleder

Jan Erik Otterstad
ved Medisinsk klinikk ved Sykehuset i Vestfold HF

prosjekteier / koordinerende forskningsansvarlig enhet

  • Medisinsk klinikk ved Sykehuset i Vestfold HF

Godkjenninger

  • Regionale komitéer for medisinsk og helsefaglig forskningsetikk (REK)

Klassifisering

Vitenskapsdisipliner

Kardiologi

Tidsramme

Avsluttet
Start: 25. februar 2013 Slutt: 31. desember 2017

Beskrivelse Beskrivelse

Tittel

3 dimensional echocardiography in severity grading of aortic stenosis and coronary heart disease

Sammendrag

Nytten av 3D ekkokardiografi ved evaluering av pasienter med aortastenose (trang klaff på hovedpulsåren) og pasienter med brystsmerter.

Vitenskapelig sammendrag

To what extent is additional transthoracic (TT) 3 dimensional echocardiography (3DE) of clinical benefit in comparison with TT 2DE in:(1) The assessment of aortic stenosis (AS) in a general Cardiology Department without an invasive laboratory or cardiac surgery? (2) Strain evaluation of patients presenting with chest pain suggestive of acute coronary syndrome in the risk stratification for invasive management.

Metode

1.Patients will be recruited from the Cardiology outpatient clinic and the general hospital wards in Toensberg, along with the two practicing cardiologists in our county (dr. Jan Berg Johansen and dr. Jarle Flaatten) and also the hospitals in Drammen, Skien and Arendal. Only patients already referred to Rikshospitalet for possible surgical treatment or trans-catheter aortic valve implantation (TAVI) will be considered for inclusion. The task of a secretary involved, Merethe Bellsund, will be to trace these patients so that the study group in Toensberg can approach them with the patient information and informed consent form (appendix 2) and submit them to an additional 2D and 3D echocardiographic examination including strain measurements provided informed written consent has been obtained. At Rikshospitalet the patients will undergo standard preoperative investigations. In addition, the patients selected for AVR will have a CT of the aortic root to compare measurments with those found on ecchocardiography. 2. Patients presenting with chest pain suggestive of ACS referred to both hospitals will be included over a period of one year. We seek to include a minimum of 200 patients recruited jointly from Toensberg and Arendal. The latter hospital has ample experience in this field and has already started recruitment of patients per March 2012 Patients will be categorized in 3 groups based on findings at admission and during observations:1. Non-ACS group*: Patients without ECG-changes** or rise in Troponin-T2. UAP group: Patients with unspecific ECG-changes without rise Troponin-T3. NSTEMI-group: Patients without initial ECG-changes**, with normal Troponin-T at admission but with rise in Troponin-T 6-8 hrs after admission (cut-off value 30 mg/L).* This group includes patients who may be given either the diagnosis UAP based upon Braunwakds criteria (subgroup without ECG changes) or NSCP according to the assessment of the attending cardiologist

Utstyr

GE VIVID E9 and Echopac vers. 12

prosjektdeltakere

prosjektleder

Jan Erik Otterstad

  • Tilknyttet:
    Prosjektleder
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

Ingvild Billehaug Norum

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF
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