Sammendrag
Due to its social attributes, its learning capabilities, and several
facultative physiological and behavioural traits under social control, the
honeybee provides opportunities for cutting-edge research not possessed by the
Drosophila, Caenorhabditis elegans, zebrafish and the mice systems. The
honeybee genome sequence is expected to be finished in May 2003, and the
annotation groups are currently being set up. The availability of the honeybee
sequence will very soon induce a substantial demand for a targeted gene
knockout technology that will be critical for the establishment of the
honeybee as a model animal for functional genomic research. We would like to
take advantage of the fact that we are currently at the research front
concerning the use of RNA interference (RNAi) technology for targeted gene
disruption in honeybees. Together with our collaborators, we want to keep our
position by further developing the RNAi methodology, so that it can become a
general and flexible tool for honeybee functional genomics.
The other main objective of this proposal is to make active use of the RNAi
approach together with sequence information from our collaborators and the
honeybee genome project to gain a deeper understanding of the regulatory
anatomy of honeybee ageing and senescence. We are at the research front of
honeybee ageing biology, and we think that continuation of our research
provide opportunities for gaining a deeper understanding of hormonal
regulation of key somatic maintenance functions in general.
NFR 157851
Vis fullstendig beskrivelse
Vitenskapelig sammendrag
Due to its social attributes, its learning capabilities, and several
facultative physiological and behavioural traits under social control, the
honeybee provides opportunities for cutting-edge research not possessed by the
Drosophila, Caenorhabditis elegans, zebrafish and the mice systems. The
honeybee genome sequence is expected to be finished in May 2003, and the
annotation groups are currently being set up. The availability of the honeybee
sequence will very soon induce a substantial demand for a targeted gene
knockout technology that will be critical for the establishment of the
honeybee as a model animal for functional genomic research. We would like to
take advantage of the fact that we are currently at the research front
concerning the use of RNA interference (RNAi) technology for targeted gene
disruption in honeybees. Together with our collaborators, we want to keep our
position by further developing the RNAi methodology, so that it can become a
general and flexible tool for honeybee functional genomics.
The other main objective of this proposal is to make active use of the RNAi
approach together with sequence information from our collaborators and the
honeybee genome project to gain a deeper understanding of the regulatory
anatomy of honeybee ageing and senescence. We are at the research front of
honeybee ageing biology, and we think that continuation of our research
provide opportunities for gaining a deeper understanding of hormonal
regulation of key somatic maintenance functions in general.
NFR 157851
Vis fullstendig beskrivelse