Cristin-prosjekt-ID: 415787
Sist endret: 9. januar 2015, 15:47

Cristin-prosjekt-ID: 415787
Sist endret: 9. januar 2015, 15:47
Prosjekt

Utvikling og bruk av RNA interferens-teknologi for videre forståelse av hvordanavgjørende somatiske vedlikeholdsfunksjoner i bier reguleres

prosjektleder

Gro Vang Amdam
ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

Klassifisering

Vitenskapsdisipliner

Genetikk og genomikk

Tidsramme

Avsluttet
Start: 1. oktober 2003 Slutt: 30. september 2005

Beskrivelse Beskrivelse

Tittel

Utvikling og bruk av RNA interferens-teknologi for videre forståelse av hvordanavgjørende somatiske vedlikeholdsfunksjoner i bier reguleres

Sammendrag

Due to its social attributes, its learning capabilities, and several facultative physiological and behavioural traits under social control, the honeybee provides opportunities for cutting-edge research not possessed by the Drosophila, Caenorhabditis elegans, zebrafish and the mice systems. The honeybee genome sequence is expected to be finished in May 2003, and the annotation groups are currently being set up. The availability of the honeybee sequence will very soon induce a substantial demand for a targeted gene knockout technology that will be critical for the establishment of the honeybee as a model animal for functional genomic research. We would like to take advantage of the fact that we are currently at the research front concerning the use of RNA interference (RNAi) technology for targeted gene disruption in honeybees. Together with our collaborators, we want to keep our position by further developing the RNAi methodology, so that it can become a general and flexible tool for honeybee functional genomics. The other main objective of this proposal is to make active use of the RNAi approach together with sequence information from our collaborators and the honeybee genome project to gain a deeper understanding of the regulatory anatomy of honeybee ageing and senescence. We are at the research front of honeybee ageing biology, and we think that continuation of our research provide opportunities for gaining a deeper understanding of hormonal regulation of key somatic maintenance functions in general. NFR 157851

Vitenskapelig sammendrag

Due to its social attributes, its learning capabilities, and several facultative physiological and behavioural traits under social control, the honeybee provides opportunities for cutting-edge research not possessed by the Drosophila, Caenorhabditis elegans, zebrafish and the mice systems. The honeybee genome sequence is expected to be finished in May 2003, and the annotation groups are currently being set up. The availability of the honeybee sequence will very soon induce a substantial demand for a targeted gene knockout technology that will be critical for the establishment of the honeybee as a model animal for functional genomic research. We would like to take advantage of the fact that we are currently at the research front concerning the use of RNA interference (RNAi) technology for targeted gene disruption in honeybees. Together with our collaborators, we want to keep our position by further developing the RNAi methodology, so that it can become a general and flexible tool for honeybee functional genomics. The other main objective of this proposal is to make active use of the RNAi approach together with sequence information from our collaborators and the honeybee genome project to gain a deeper understanding of the regulatory anatomy of honeybee ageing and senescence. We are at the research front of honeybee ageing biology, and we think that continuation of our research provide opportunities for gaining a deeper understanding of hormonal regulation of key somatic maintenance functions in general. NFR 157851

Tittel

Development and application of RNA interference technology for understanding the regulation of key somatic maintenance functions in honeybees

Sammendrag

Due to its social attributes, its learning capabilities, and several facultative physiological and behavioural traits under social control, the honeybee provides opportunities for cutting-edge research not possessed by the Drosophila, Caenorhabditis elegans, zebrafish and the mice systems. The honeybee genome sequence is expected to be finished in May 2003, and the annotation groups are currently being set up. The availability of the honeybee sequence will very soon induce a substantial demand for a targeted gene knockout technology that will be critical for the establishment of the honeybee as a model animal for functional genomic research. We would like to take advantage of the fact that we are currently at the research front concerning the use of RNA interference (RNAi) technology for targeted gene disruption in honeybees. Together with our collaborators, we want to keep our position by further developing the RNAi methodology, so that it can become a general and flexible tool for honeybee functional genomics. The other main objective of this proposal is to make active use of the RNAi approach together with sequence information from our collaborators and the honeybee genome project to gain a deeper understanding of the regulatory anatomy of honeybee ageing and senescence. We are at the research front of honeybee ageing biology, and we think that continuation of our research provide opportunities for gaining a deeper understanding of hormonal regulation of key somatic maintenance functions in general.

Vitenskapelig sammendrag

Due to its social attributes, its learning capabilities, and several facultative physiological and behavioural traits under social control, the honeybee provides opportunities for cutting-edge research not possessed by the Drosophila, Caenorhabditis elegans, zebrafish and the mice systems. The honeybee genome sequence is expected to be finished in May 2003, and the annotation groups are currently being set up. The availability of the honeybee sequence will very soon induce a substantial demand for a targeted gene knockout technology that will be critical for the establishment of the honeybee as a model animal for functional genomic research. We would like to take advantage of the fact that we are currently at the research front concerning the use of RNA interference (RNAi) technology for targeted gene disruption in honeybees. Together with our collaborators, we want to keep our position by further developing the RNAi methodology, so that it can become a general and flexible tool for honeybee functional genomics. The other main objective of this proposal is to make active use of the RNAi approach together with sequence information from our collaborators and the honeybee genome project to gain a deeper understanding of the regulatory anatomy of honeybee ageing and senescence. We are at the research front of honeybee ageing biology, and we think that continuation of our research provide opportunities for gaining a deeper understanding of hormonal regulation of key somatic maintenance functions in general.

prosjektdeltakere

prosjektleder

Gro Vang Amdam

  • Tilknyttet:
    Prosjektleder
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

Stig William Omholt

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

Randi Aamodt

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
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