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Cristin-prosjekt-ID:
415815
Sist endret:
18. desember 2013, 14:56
Historikk
Cristin-prosjekt-ID:
415815
Sist endret:
18. desember 2013, 14:56
Prosjekt
Hvordan lipidmetabolismen reguleres av fettsyrer i svin
prosjektleder
prosjektleder
Sigbjørn Lien
ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
prosjekteier / koordinerende forskningsansvarlig enhet
prosjekteier / koordinerende forskningsansvarlig enhet
Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
Klassifisering
Klassifisering
Vitenskapsdisipliner
Genetikk og genomikk • Bioteknologi
Tidsramme
Tidsramme
Avsluttet
Start:
1. januar 2004
Slutt:
30. september 2007
Beskrivelse
Beskrivelse
Norsk
Engelsk
Tittel
Hvordan lipidmetabolismen reguleres av fettsyrer i svin
Sammendrag
Principal objective: Elucidate the genomic response to PPAR agonists and selective fatty acids on lipid metabolism in pig by transcript profiling and functional studies in vitro, particularly in relation to development, accumulation and breakdown of lipids in muscle and adipose tissue. Subgoals: 1) Elucidate the in vitro gene expression pattern during adipogenesis in porcine subcutaneous adipose tissue by use of high-throughput technology. 2) Determine the relative activation of the different PPARs by selective agonists and fatty acids by reporter gene studies in transfected cell lines. 3) Investigate the genomic response to PPAR-agonists and selective fatty acids in primary cultures of differentiated adipocytes and muscle. 4) Perform in vivogene expression pattern analysis of a selected number of genes. NFR 159408
Vis
fullstendig beskrivelse
Vitenskapelig sammendrag
Principal objective: Elucidate the genomic response to PPAR agonists and selective fatty acids on lipid metabolism in pig by transcript profiling and functional studies in vitro, particularly in relation to development, accumulation and breakdown of lipids in muscle and adipose tissue. Subgoals: 1) Elucidate the in vitro gene expression pattern during adipogenesis in porcine subcutaneous adipose tissue by use of high-throughput technology. 2) Determine the relative activation of the different PPARs by selective agonists and fatty acids by reporter gene studies in transfected cell lines. 3) Investigate the genomic response to PPAR-agonists and selective fatty acids in primary cultures of differentiated adipocytes and muscle. 4) Perform in vivogene expression pattern analysis of a selected number of genes. NFR 159408
Vis
fullstendig beskrivelse
Tittel
Regulation of lipid metabolism by fatty acids in swine - a functional genomic approach
Sammendrag
Principal objective: Elucidate the genomic response to PPAR agonists and selective fatty acids on lipid metabolism in pig by transcript profiling and functional studies in vitro, particularly in relation to development, accumulation and breakdown of lipids in muscle and adipose tissue. Subgoals: 1) Elucidate the in vitro gene expression pattern during adipogenesis in porcine subcutaneous adipose tissue by use of high-throughput technology. 2) Determine the relative activation of the different PPARs by selective agonists and fatty acids by reporter gene studies in transfected cell lines. 3) Investigate the genomic response to PPAR-agonists and selective fatty acids in primary cultures of differentiated adipocytes and muscle. 4) Perform in vivogene expression pattern analysis of a selected number of genes.
Vis
fullstendig beskrivelse
Vitenskapelig sammendrag
Principal objective: Elucidate the genomic response to PPAR agonists and selective fatty acids on lipid metabolism in pig by transcript profiling and functional studies in vitro, particularly in relation to development, accumulation and breakdown of lipids in muscle and adipose tissue. Subgoals: 1) Elucidate the in vitro gene expression pattern during adipogenesis in porcine subcutaneous adipose tissue by use of high-throughput technology. 2) Determine the relative activation of the different PPARs by selective agonists and fatty acids by reporter gene studies in transfected cell lines. 3) Investigate the genomic response to PPAR-agonists and selective fatty acids in primary cultures of differentiated adipocytes and muscle. 4) Perform in vivogene expression pattern analysis of a selected number of genes.
Vis
fullstendig beskrivelse
prosjektdeltakere
prosjektdeltakere
prosjektleder
Sigbjørn Lien
Prosjektleder
ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
Johanna Samulin
Prosjektdeltaker
ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
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