Cristin-prosjekt-ID: 415915
Sist endret: 20. desember 2013, 14:55

Cristin-prosjekt-ID: 415915
Sist endret: 20. desember 2013, 14:55
Prosjekt

Dissecting the physiological, sensory, cognitive, and social dynamic featuresof cellular aging in the honey bee worker brain

prosjektleder

Gro Vang Amdam
ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

Klassifisering

Vitenskapsdisipliner

Husdyravl, oppdrett, forplantning

Emneord

Aldring • Livslengde

Tidsramme

Avsluttet
Start: 1. april 2006 Slutt: 31. desember 2007

Beskrivelse Beskrivelse

Tittel

Dissecting the physiological, sensory, cognitive, and social dynamic featuresof cellular aging in the honey bee worker brain

Sammendrag

The honey bee is a key neurobiological model for understanding learning and memory formation. As a highly social invertebrate, moreover, the bee provides unique opportunities for cutting-edge research on aging and frailty because it opens up the interface between the individual and the social environment. Our group at UMB's Department of Animal and Aquacultural Sciences has over the last five years contributed to a deeper understanding of the regulation of honey bee lifespan. We have, e.g., shown that aging in worker bees is not a clear-cut function of chronological age. This is because aging can be controlled by social signals through a feedback pathway that involves the systemic hormone juvenile hormone and the gene vitellogenin. Recently, we started to investigate whether oxidative brain damage, a hallmark of aging, can be affected by social signals as well. Our preliminary data, obtained from immunohistochemical staining of 150 brains from 8­200 day-old workers, suggests that this is indeed the case. The proposal presented here outlines how we intend to move forward in our work to understand the pathology and social regulation of honey bee brain aging. Explicitly, we want to take advantage of the fact that we are at the research forefront in the field of honey bee longevity regulation; mastering a broad range of key techniques including brain immunohistochemistry, RNA interference methodology, immuno- and ligand-blot procedures. From this foundation, we will first dissect the pathology of bee brain aging in collaboration with Dr. Gimsa (Sub-goal 1). Next, together with Dr. Scheiner, who is an expert in the use of the bee as a neurobiological model, we will establish how brain aging affects the bee's sensory sensitivity and cognitive abilities (Sub-goal 2). Finally, we will determine the extent of which the pathologies mapped under sub-goals 1 and 2 can be controlled, and possibly reversed, by social signals (Sub­goal 3). NFR 171958 - kontraktspartner overfor NFR: UMB/IHA

Vitenskapelig sammendrag

The honey bee is a key neurobiological model for understanding learning and memory formation. As a highly social invertebrate, moreover, the bee provides unique opportunities for cutting-edge research on aging and frailty because it opens up the interface between the individual and the social environment. Our group at UMB's Department of Animal and Aquacultural Sciences has over the last five years contributed to a deeper understanding of the regulation of honey bee lifespan. We have, e.g., shown that aging in worker bees is not a clear-cut function of chronological age. This is because aging can be controlled by social signals through a feedback pathway that involves the systemic hormone juvenile hormone and the gene vitellogenin. Recently, we started to investigate whether oxidative brain damage, a hallmark of aging, can be affected by social signals as well. Our preliminary data, obtained from immunohistochemical staining of 150 brains from 8­200 day-old workers, suggests that this is indeed the case. The proposal presented here outlines how we intend to move forward in our work to understand the pathology and social regulation of honey bee brain aging. Explicitly, we want to take advantage of the fact that we are at the research forefront in the field of honey bee longevity regulation; mastering a broad range of key techniques including brain immunohistochemistry, RNA interference methodology, immuno- and ligand-blot procedures. From this foundation, we will first dissect the pathology of bee brain aging in collaboration with Dr. Gimsa (Sub-goal 1). Next, together with Dr. Scheiner, who is an expert in the use of the bee as a neurobiological model, we will establish how brain aging affects the bee's sensory sensitivity and cognitive abilities (Sub-goal 2). Finally, we will determine the extent of which the pathologies mapped under sub-goals 1 and 2 can be controlled, and possibly reversed, by social signals (Sub­goal 3). NFR 171958 - kontraktspartner overfor NFR: UMB/IHA

prosjektdeltakere

prosjektleder

Gro Vang Amdam

  • Tilknyttet:
    Prosjektleder
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

Siri-Christine Seehuus

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
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Resultater Resultater

A diapause pathway underlies the gyne phenotype in Polistes wasps, revealing an evolutionary route to caste-containing insect societies.

Hunt, James H.; Kensinger, Bart J.; Kossuth, Jessica A.; Henshaw, Michael T.; Norberg, Kari; Wolschin, Florian; Amdam, Gro Vang. 2007, Proceedings of the National Academy of Sciences of the United States of America. UoML, ASU, NMBU, MCVitenskapelig artikkel

Variation in endocrine signaling underlies variation in social life history.

Amdam, Gro Vang; Nilsen, Kari-Anne; Norberg, Kari; Fondrk, M. Kim; Hartfelder, Klaus. 2007, The American Naturalist. ASU, UdSP, NMBUVitenskapelig artikkel

The making of a social insect: developmental architectures of social design.

Page, Robert E. Jr.; Amdam, Gro Vang. 2007, Bioessays. ASU, NMBUVitenskapelig artikkel

The Making of a Queen: TOR Pathway Is a Key Player in Diphenic Caste Development.

Patel, Avani; Fondrk, M. Kim; Kaftanoglu, Osman; Emore, Christine; Hunt, Greg; Frederick, Katy; Amdam, Gro Vang. 2007, PLOS ONE. ASU, PU, NMBUVitenskapelig artikkel
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