Cristin-prosjekt-ID: 417812
Sist endret: 21. oktober 2020 23:34

Cristin-prosjekt-ID: 417812
Sist endret: 21. oktober 2020 23:34
Prosjekt

Biology-Driven Synthesis – from Marine Natural Products to Commercial Leads

prosjektleder

Annette Bayer
ved Institutt for kjemi ved UiT Norges arktiske universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Institutt for kjemi ved UiT Norges arktiske universitet

Finansiering

  • Norges forskningsråd
    Prosjektkode: 224790

Klassifisering

Vitenskapsdisipliner

Bioteknologi

Kategorier

Prosjektkategori

  • Anvendt forskning

Tidsramme

Avsluttet
Start: 1. mai 2013 Slutt: 31. desember 2017

Beskrivelse Beskrivelse

Tittel

Biology-Driven Synthesis – from Marine Natural Products to Commercial Leads

Vitenskapelig sammendrag

Infectious diseases are a leading cause of death worldwide and are traditionally treated with antibiotics. Today, society faces an urgent need for new antimicrobial agents and strategies due to the emergence and spread of antibiotic resistant bacteria leading to infections that cannot be treated with antibiotics. This research proposal aims to develop new antimicrobial agents based on marine bioactive compounds. The project is a multi-disciplinary collaboration of scientists from the four Norwegian universities in Tromsø, Bergen, Stavanger and Trondheim (UoT, UoB, UoS and NTNU) acting together with the biodiscovery centre at UoT (MabCent-SFI) - a Centre of Research Based Innovation on Marine Bioactives and Drug Discovery. The research team consists of specialists in organic synthesis, drug design, biochemistry, microbiology and more. Herein, we outline a systematic approach for developing bioactive natural products, isolated and characterized by scientists at MabCent, into lead compounds for new antimicrobial agents. Discovery of other bioactivities associated with the natural products and their synthetic derivatives will also be followed up through the MabCent consortium. The original structure will be systematically modified to gain an understanding of the structural features that are important for the biological activity through structure-activity relationship (SAR) studies. This will involve the following steps: (1) development of efficient synthetic strategies, (2) preparation of a natural product focused library of compounds, and (3) biological screening and investigation of the library. We aim at a close interaction between activities in synthesis and biological screening, i.e. compounds prepared will be screened consecutively, and thus biological data will continuously be feed into the design process. In essence, biology will be in the driver seat and the research will move forward in an iterative process.

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Annette Bayer

  • Tilknyttet:
    Prosjektleder
    ved Institutt for kjemi ved UiT Norges arktiske universitet

Odd Reidar Gautun

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for kjemi ved Norges teknisk-naturvitenskapelige universitet

Bengt Erik Haug

  • Tilknyttet:
    Prosjektdeltaker
    ved Kjemisk institutt ved Universitetet i Bergen

Kåre Bredeli Jørgensen

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for matematikk og fysikk ved Universitetet i Stavanger
Aktiv cristin-person

Magne Olav Sydnes

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for matematikk og fysikk ved Universitetet i Stavanger
  • Tilknyttet:
    Prosjektdeltaker
    ved NORCE Miljø ved NORCE Norwegian Research Centre AS
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Resultater Resultater

Total Synthesis of Phorbazole B.

Guttormsen, Yngve; Fairhurst, Magnus John Espeland; Pandey, Sunil Kumar; Isaksson, Johan; Haug, Bengt Erik; Bayer, Annette. 2020, Molecules. UIT, UIBVitenskapelig artikkel

Unequivocal Structure Confirmation of a Breitfussin Analog by Anisotropic NMR Measurements.

Ndukwe, Ikenna E.; Lam, Yu-hong; Pandey, Sunil Kumar; Haug, Bengt Erik; Bayer, Annette; Sherer, Edward C.; Blinov, Kirill A.; Williamson, R. Thomas; Isaksson, Johan; Reibarkh, Mikhail mfl.. 2020, Chemical Science. UIT, UIBVitenskapelig artikkel

Kinase chemodiversity from the Arctic: the breitfussins.

Østnes Hansen, Kine; Andersen, Jeanette hammer; Bayer, Annette; Pandey, Sunil Kumar; Lorentzen, Marianne; Jørgensen, Kåre Bredeli; Sydnes, Magne Olav; Guttormsen, Yngve; Baumann, Matthias; Koch, Uwe mfl.. 2019, Journal of Medicinal Chemistry. UIT, LDC, UIS, UIBVitenskapelig artikkel

Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character.

Paulsen, Marianne Hagensen; Ausbacher, Dominik; Bayer, Annette; Engqvist, Magnus; Hansen, Terkel; Haug, Tor; Anderssen, Trude; Andersen, Jeanette hammer; Sollid, Johanna U Ericson; Strøm, Morten B.. 2019, European Journal of Medicinal Chemistry. UIT, APOTEKNORDVitenskapelig artikkel

Total synthesis of Breitfussin A and B.

Bayer, Annette. 2018, 5th meeting of COST action CM1407. UITVitenskapelig foredrag
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