Cristin-prosjekt-ID: 437758
Sist endret: 4. desember 2017, 22:18

Cristin-prosjekt-ID: 437758
Sist endret: 4. desember 2017, 22:18
Prosjekt

PRV PROTect - Targeting piscine orthoreovirus (PRV) infection in Norwegian Atlantic salmon aquaculture

prosjektleder

Vidar Aspehaug
ved PatoGen Analyse AS

prosjekteier / koordinerende forskningsansvarlig enhet

  • PatoGen Analyse AS

Finansiering

  • Norges forskningsråd
    Prosjektkode: 235788

Klassifisering

Vitenskapsdisipliner

Infeksjonsmedisin • Akvakultur • Fiskehelse

Emneord

RNA-virus • Lakseoppdrett • Fiskefysiologi

Kategorier

Prosjektkategori

  • Anvendt forskning

Tidsramme

Avsluttet
Start: 1. april 2014 Slutt: 31. mars 2017

Beskrivelse Beskrivelse

Tittel

PRV PROTect - Targeting piscine orthoreovirus (PRV) infection in Norwegian Atlantic salmon aquaculture

Vitenskapelig sammendrag

Norwegian salmon aquaculture have in the last two decades experienced an increasing number of outbreaks from heart- and skeletal muscle inflammation (HSMI), a disease associated with the piscine orthoreovirus (PRV). PRV is ubiquitous in farmed and wild salmon globally, and a better understanding of the effects of this virus on fish health is needed. The virus also appears to be present in fish with no clinical signs of disease. This project aim to increase the understanding of how to protect the fish from HSMI, and to what extent the spread of PRV can be limited and controlled by targeted strategies. PatoGen, Marine Harvest, the Norwegian Veterinary Institute (NVI) and the Norwegian School of Veterinary Science (NVH) have joined forces in this project with the aim for better control and increased understanding of the role of PRV for disease development. Patogen Analyse have previously performed extensive mapping of PRV in fish farms and recently developed phylogenetic tools to screen for viral variants and thereby uncover the source and spread of the virus. In this project we will map the infection routes more closely, aiming to limit viral spread and study the link between the virus and the health status of the fish. Recent studies on PRV pathogenesis have been performed by the researchers from NVI and NVH involved in this project, and have revealed that the virus infects red blood cells prior to the infection of the myocytes of the heart. A PRV infection in blood cells may potentially have consequences for the health state and production state of the salmon. It is natural to hypothesize that the primary properties of the fish blood cells, including oxygen transport and oxygen delivery to muscle tissue, may be affected and that this can reduce fitness and robustness of the fish. The inflammatory injury to heart and muscle observed for HSMI may also be oxygen deprivation, and this will be studied alongside other possible consequences of a PRV infection. We wish to develop better tools and strategies to monitor PRV infection, spread and effects on the robustness and health state of the fish. This may be of importance for a more robust and sustainable aquaculture.

prosjektdeltakere

prosjektleder

Vidar Aspehaug

  • Tilknyttet:
    Prosjektleder
    ved PatoGen Analyse AS

Morten Lund

  • Tilknyttet:
    Prosjektdeltaker
    ved Epidemiologi ved Veterinærinstituttet

Ingvild Berg Nyman

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet
Aktiv cristin-person

Maria Dahle

  • Tilknyttet:
    Prosjektdeltaker
    ved Forskningsgruppe fiskehelse ved Veterinærinstituttet

Espen Rimstad

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet
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Resultater Resultater

DNA vaccine expressing the non-structural proteins of Piscine orthoreovirus delay the kinetics of PRV infection and induces moderate protection against heart -and skeletal muscle inflammation in Atlantic salmon (Salmo salar).

Haatveit, Hanne Merethe; Hodneland, Kjartan; Braaen, Stine; Hansen, Elisabeth Furuseth; Nyman, Ingvild Berg; Dahle, Maria; Frost, Petter; Rimstad, Espen. 2018, Vaccine. VETINST, NMBU, DIVNORSKVitenskapelig artikkel

Hypoxia tolerance and responses to hypoxic stress during heart and skeletal muscle inflammation in Atlantic salmon (Salmo salar).

Lund, Morten; Dahle, Maria Krudtaa; Timmerhaus, Gerrit; Alarcon, Marta; Powell, Mark; Aspehaug, Vidar; Rimstad, Espen; Jørgensen, Sven Martin. 2017, 18th International Conference on Diseases of Fish and Shellfish. VETINST, NMBU, UIO, UIBVitenskapelig foredrag

Effekter av Piscine orthoreovirus (PRV) infeksjon på robusthet hos laks – mer enn HSMB? .

Lund, Morten; Aspehaug, Vidar; Jørgensen, Sven Martin; Rimstad, Espen; Dahle, Maria Krudtaa. 2017, Frisk Fisk . VETINST, NMBUVitenskapelig foredrag

Hypoxia tolerance and responses to hypoxic stress during heart and skeletal muscle inflammation in Atlantic salmon (Salmo salar).

Lund, Morten; Dahle, Maria Krudtaa; Timmerhaus, Gerrit; Alarcon, Marta; Powell, Mark; Aspehaug, Vidar; Rimstad, Espen; Jørgensen, Sven Martin. 2017, PLOS ONE. NIVA, VETINST, PATOGEN, NMBU, NOFIMA, UIBVitenskapelig artikkel

Immunological interactions between Piscine orthoreovirus and Salmonid alphavirus infections in Atlantic salmon.

Røsæg, Magnus Vikan; Lund, Morten; Nyman, Ingvild Berg; Markussen, Turhan; Aspehaug, Vidar; Sindre, Hilde; Dahle, Maria Krudtaa; Rimstad, Espen. 2017, Fish and Shellfish Immunology. VETINST, NMBU, PATOGEN, SALMARVitenskapelig artikkel
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