Cristin-prosjekt-ID: 454671
Sist endret: 5. desember 2017, 14:32

Cristin-prosjekt-ID: 454671
Sist endret: 5. desember 2017, 14:32
Prosjekt

HSMImore: Effects of PRV-infection on salmon robustness- more than HSMI

prosjektleder

Maria Dahle
ved Forskningsgruppe fiskehelse ved Veterinærinstituttet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Forskningsgruppe fiskehelse ved Veterinærinstituttet

Finansiering

  • TotalbudsjettNOK 4.050.000
  • Fiskeri- og havbruksnæringens forskningsfinansiering
    Prosjektkode: 901001

Klassifisering

Vitenskapsdisipliner

Infeksjonsmedisin • Akvakultur • Fiskehelse • Human og veterinærmedisinsk fysiologi

Emneord

Lakseoppdrett • Smoltproduksjon • Fiskefysiologi • RNA-virusinfeksjoner

HRCS-forskningsaktivitet

  • 1 Underbyggende Forskning
  • 4 Påvising, screening og diagnose

Kategorier

Prosjektkategori

  • Anvendt forskning

Tidsramme

Avsluttet
Start: 1. august 2014 Slutt: 30. desember 2016

Beskrivelse Beskrivelse

Tittel

HSMImore: Effects of PRV-infection on salmon robustness- more than HSMI

Vitenskapelig sammendrag

Viral infections are among the main challenges linked to loss and reduced growth and performance of farmed salmon in Norway. This project aims to increase the understanding of the interplay between virus, host and environment, to be able to optimize protective procedures.

Heart and skeletal muscle inflammation (HSMI) is according to the recent fish health reports from the Norwegian Veterinary Institute the viral disease that has affected Norwegian Atlantic salmon aquaculture most strongly since 2011. The virus associated with HSMI, piscine orthoreovirus (PRV), is widely found in farmed fish following transfer to sea water, and has in the last two years been detected also in fresh water smolt facilities in Norway, in wild salmonids, and in most other countries farming Atlantic salmon (Chile, Canada, Great Britain and Ireland).

The loss of fish due to HSMI is variable, and the interaction between viral infection and other conditions is complex.  In this project we will study the interaction between PRV infection and stress sensitivity, smoltification and secondary infections in challenge models.  The recent findings showing that PRV can infect more than half of the salmon erythrocytes in the peak phase of infection strongly suggests that PRV infection can affects oxygen uptake. Other findings also indicate that the viral infection changes the immune function of blood cells.

The goal of this project is to perform experimental challenge studies to test three main hypotheses that link PRV infection to reduced salmon robustness

Hypotesis 1:  PRV infection affects the quality of smoltification.
Hypotesis 2:  PRV infection reduces the tolerance to low oxygen conditions and increased oxygen need (stress).
Hypotesis 3:  PRV infection makes the fish more sensitive to secondary viral infections, with focus on salmonid alphavirus (SAV) and pancreas disease (PD).

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Maria Dahle

  • Tilknyttet:
    Prosjektleder
    ved Forskningsgruppe fiskehelse ved Veterinærinstituttet

Morten Lund

  • Tilknyttet:
    Prosjektdeltaker
    ved Epidemiologi ved Veterinærinstituttet

Sven Martin Jørgensen

  • Tilknyttet:
    Prosjektdeltaker
    ved Fiskehelse ved NOFIMA
Aktiv cristin-person

Torunn Taksdal

  • Tilknyttet:
    Prosjektdeltaker
    ved Fiskehelse og biosikkerhet ved Veterinærinstituttet

Vidar Aspehaug

  • Tilknyttet:
    Prosjektdeltaker
    ved PatoGen Analyse AS
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Resultater Resultater

Hypoxia tolerance and responses to hypoxic stress during heart and skeletal muscle inflammation in Atlantic salmon (Salmo salar).

Lund, Morten; Dahle, Maria Krudtaa; Timmerhaus, Gerrit; Alarcon, Marta; Powell, Mark; Aspehaug, Vidar; Rimstad, Espen; Jørgensen, Sven Martin. 2017, 18th International Conference on Diseases of Fish and Shellfish. VETINST, NMBU, UIO, UIBVitenskapelig foredrag

Effekter av Piscine orthoreovirus (PRV) infeksjon på robusthet hos laks – mer enn HSMB? .

Lund, Morten; Aspehaug, Vidar; Jørgensen, Sven Martin; Rimstad, Espen; Dahle, Maria Krudtaa. 2017, Frisk Fisk . VETINST, NMBUVitenskapelig foredrag

Hypoxia tolerance and responses to hypoxic stress during heart and skeletal muscle inflammation in Atlantic salmon (Salmo salar).

Lund, Morten; Dahle, Maria Krudtaa; Timmerhaus, Gerrit; Alarcon, Marta; Powell, Mark; Aspehaug, Vidar; Rimstad, Espen; Jørgensen, Sven Martin. 2017, PLOS ONE. NIVA, VETINST, PATOGEN, NMBU, NOFIMA, UIBVitenskapelig artikkel

Immunological interactions between Piscine orthoreovirus and Salmonid alphavirus infections in Atlantic salmon.

Røsæg, Magnus Vikan; Lund, Morten; Nyman, Ingvild Berg; Markussen, Turhan; Aspehaug, Vidar; Sindre, Hilde; Dahle, Maria Krudtaa; Rimstad, Espen. 2017, Fish and Shellfish Immunology. VETINST, NMBU, PATOGEN, SALMARVitenskapelig artikkel

Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar).

Lund, Morten; Røsæg, Magnus Vikan; Krasnov, Aleksei; Timmerhaus, Gerrit; Nyman, Ingvild Berg; Aspehaug, Vidar; Rimstad, Espen; Dahle, Maria Krudtaa. 2016, Veterinary research (VR). VETINST, NMBU, PATOGEN, SALMAR, NOFIMAVitenskapelig artikkel
1 - 5 av 6 | Neste | Siste »