Cristin-prosjekt-ID: 454673
Sist endret: 12. mai 2018 14:09
Cristin-prosjekt-ID: 454673
Sist endret: 12. mai 2018 14:09
Prosjekt

ViVaFish - Platform for Fish Virus Vaccines

prosjektleder

Espen Rimstad
ved Institutt for mattrygghet og infeksjonsbiologi ved Norges miljø- og biovitenskapelige universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Norges miljø- og biovitenskapelige universitet

Finansiering

  • Norges forskningsråd

    • Prosjektkode: 237315

Klassifisering

Vitenskapsdisipliner

Infeksjonsmedisin • Fiskehelse

Emneord

Virus • Fiskeimmunologi • Lakseoppdrett • Fiskevaksine

Kategorier

Prosjektkategori

  • Grunnforskning

Tidsramme

Avsluttet
Start: 1. august 2015 Slutt: 31. juli 2018

Beskrivelse Beskrivelse

Tittel

ViVaFish - Platform for Fish Virus Vaccines

Vitenskapelig sammendrag

Viral diseases represent a huge problem for the global aquaculture industry, and many viral diseases cannot be effectively controlled using the current generation of vaccines. Therefore, new vaccine strategies need to be developed, and basic scientific issues regarding virus agents, host-virus interactions, and the establishment of long term immune protection need to be addressed. Sustainable and environmentally responsible aquaculture in Norway and the rest of the world will require a better understanding of: (i) the immune system in fish; (ii) the interaction between viruses and hosts; (iii) the biological basis for protection; and (iv) the design of more effective viral vaccines for fish.

Members of the ViVaFish consortium have made major breakthroughs by identifyingPiscine orthoreovirus(PRV) andPiscine myocarditis virus(PMCV), which cause the emerging diseases Heart and skeletal muscle inflammation (HSMI), and Cardiomyopathy syndrome (CMS), respectively.  Together the principal investigators have long experience in fish virology, immunology and vaccinology and have published pioneering studies of the Atlantic salmon type I IFN system, immunoprotective responses of salmon after vaccination and protective subgenomic alphavirus replicon vaccines.

The overall aim of the platform is to generate new knowledge, tools, and methods relevant for the vaccination of farmed fish against viral diseases. Both the sustainability and future expansion of aquaculture depends on the control of viral infections. The ViVaFish platform will bring together ten leading Norwegian researchers from major national fish virology/immunology groups in Oslo, Bergen, and Tromsø. Important scientific contributions to the ViVaFish platform will also be made from Nofima, vaccine development companies, and by many international collaborators.

Three main work packages aim to:

WP1Develop new viral vaccine concepts and improve those currently available

WP2Characterize immunological aspects of long term protection

WP3Optimize vaccine delivery and response monitoring

prosjektdeltakere

prosjektleder

Espen Rimstad

  • Tilknyttet:
    Prosjektleder
    ved Institutt for mattrygghet og infeksjonsbiologi ved Norges miljø- og biovitenskapelige universitet

Ida Aksnes

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for mattrygghet og infeksjonsbiologi ved Norges miljø- og biovitenskapelige universitet

Hanne Merethe Haatveit

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for mattrygghet og infeksjonsbiologi ved Norges miljø- og biovitenskapelige universitet

Lena Hammerlund Teige

  • Tilknyttet:
    Prosjektdeltaker
    ved Norges miljø- og biovitenskapelige universitet

Øystein Wessel

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for mattrygghet og infeksjonsbiologi ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Prosjektdeltaker
    ved Norges miljø- og biovitenskapelige universitet
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Resultater Resultater

Molecular and antigenic characterization of piscine orthoreovirus (PRV) from rainbow trout (oncorhynchus orthoreovirumykiss).

Kannimuthu, Dhamotharan; Vendramin, Niccolò; Markussen, Turhan; Wessel, Øystein; Cuenca, Argelia; Nyman, Ingvild Berg; Olsen, Anne Berit; Tengs, Torstein; Dahle, Maria; Rimstad, Espen. 2018, Viruses. VETINST, DTU, NMBUVitenskapelig artikkel

Infection with purified Piscine orthoreovirus demonstrates a causal relationship with heart and skeletal muscle inflammation in Atlantic salmon.

Wessel, Øystein; Braaen, Stine; Alarcon, Marta; Haatveit, Hanne Merethe; Roos, Norbert; Markussen, Turhan; Tengs, Torstein; Dahle, Maria Krudtaa; Rimstad, Espen. 2017, 18th International Conference on Diseases of Fish and Shellfish. VETINST, NMBU, UIOVitenskapelig foredrag

Hypoxia tolerance and responses to hypoxic stress during heart and skeletal muscle inflammation in Atlantic salmon (Salmo salar).

Lund, Morten; Dahle, Maria Krudtaa; Timmerhaus, Gerrit; Alarcon, Marta; Powell, Mark; Aspehaug, Vidar; Rimstad, Espen; Jørgensen, Sven Martin. 2017, PLoS ONE. NIVA, VETINST, PATOGEN, NMBU, NOFIMA, UIBVitenskapelig artikkel

A bead based multiplex immunoassay detects Piscine orthoreovirus specific antibodies in Atlantic salmon (Salmo salar).

Teige, Lena Hammerlund; Lund, Morten; Haatveit, Hanne Merethe; Røsæg, Magnus Vikan; Wessel, Øystein; Dahle, Maria Krudtaa; Storset, Anne. 2017, Fish and Shellfish Immunology. VETINST, NMBU, SALMARVitenskapelig artikkel

Immunological interactions between Piscine orthoreovirus and Salmonid alphavirus infections in Atlantic salmon.

Røsæg, Magnus Vikan; Lund, Morten; Nyman, Ingvild Berg; Markussen, Turhan; Aspehaug, Vidar; Sindre, Hilde; Dahle, Maria Krudtaa; Rimstad, Espen. 2017, Fish and Shellfish Immunology. VETINST, NMBU, PATOGEN, SALMARVitenskapelig artikkel
1 - 5 av 12 | Neste | Siste »