Cristin-prosjekt-ID: 503218
Sist endret: 4. februar 2016 10:09
Cristin-prosjekt-ID: 503218
Sist endret: 4. februar 2016 10:09
Prosjekt

TERPENOSOME: Engineered compartments for monoterpenoid production using synthetic biology

prosjektleder

Per Bruheim
ved Institutt for bioteknologi og matvitenskap ved Norges teknisk-naturvitenskapelige universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Norges teknisk-naturvitenskapelige universitet

Finansiering

  • TotalbudsjettNOK 3.600.000
  • Norges forskningsråd

    • Prosjektkode: 237165/O30

Tidsramme

Avsluttet
Start: 1. mars 2014 Slutt: 28. februar 2017

Beskrivelse Beskrivelse

Tittel

TERPENOSOME: Engineered compartments for monoterpenoid production using synthetic biology

Vitenskapelig sammendrag

The main objective of TERPENOSOME is to use synthetic biology to engineer novel organelles for the

overproduction of monoterpenoids in microbial hosts. We intend to achieve higher and more efficient production

than is seen naturally in plants. Compartmentalization will eliminate the toxicity problems that currently hinder

higher productivity and will also reduce side products. The engineered organelles will be either natural (peroxisomes

in yeast) or artificial (protein-based compartments in Escherichia coli).

TERPENOSOME expected results:

1) Generate a portfolio of generic methods for the compartmentalization of biosynthetic pathways for small

bioactive molecules, especially terpenoids;

2) Improve the biosynthetic enzyme systems of terpenoid biosynthesis for new and more efficient bioprocessing;

3) Overproduce an industrially relevant terpenoid, which will be commercialized by one of the partners.

Exploitation:

The potential for industrial application is extremely high for two of the main results.

First, the compartmentalization methodology we establish will be generic and can be applied to a wide range of

biotechnologically relevant high-value compounds. The participation of Life Technologies in the consortium will

accelerate the time-to-market for any of these methodological advances and the resulting improvements in

compound production.

Second, in addition to the broadly used precursor material limonene, the major target molecules of the project are

two high-value compounds of commercial interest to the second industry partner, ACS International.

prosjektdeltakere

prosjektleder

Per Bruheim

  • Tilknyttet:
    Prosjektleder
    ved Institutt for bioteknologi og matvitenskap ved Norges teknisk-naturvitenskapelige universitet
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