Cristin-prosjekt-ID: 522057
Sist endret: 4. oktober 2019 09:21

Cristin-prosjekt-ID: 522057
Sist endret: 4. oktober 2019 09:21
Prosjekt

Dissecting asthma phenotypes – a longitudinal study for better prevention and personalized treatment.

prosjektleder

Johny Kongerud
ved Lungeavdelingen ved Universitetet i Oslo

prosjekteier / koordinerende forskningsansvarlig enhet

  • Medisinsk serviceklinikk ved Sykehuset Telemark HF

Finansiering

  • Sykehuset Telemark
    Prosjektkode: 81.54

Klassifisering

Vitenskapsdisipliner

Lungesykdommer • Epidemiologi medisinsk og odontologisk statistikk

Emneord

Lungesykdommer • Astma • Epidemiologi

HRCS-helsekategori

  • Lunger og luftveier

HRCS-forskningsaktivitet

  • 2 Årsaksforhold

Kategorier

Prosjektkategori

  • Doktorgradsprosjekt

Tidsramme

Aktivt
Start: 1. august 2016 Slutt: 1. august 2022

Beskrivelse Beskrivelse

Tittel

Dissecting asthma phenotypes – a longitudinal study for better prevention and personalized treatment.

Populærvitenskapelig sammendrag

In 2013, a random sample of 50.000 inhabitants aged 16-50 living in Telemark county received a validated questionnaire regarding respiratory symptoms and occupational exposure. We have collected comprehensive clinical, inflammatory, occupational and environmental data and have for the first time in Norway applied an asthma-specific job-exposure-matrix (JEM) on a large sample (N=16.099) from the general population. The aim of the study is to analyze this unique data set for identifying clinical distinct phenotypes in asthma, possible risk factors and ultimately more personalized treatment for asthma patients.

Vitenskapelig sammendrag

Asthma is a heterogenic disease with different phenotypes. However, there are patients not fitting into the phenotypes and no consensus on definitions. There is a lack of studies on samples from the general population and the stability of phenotypes. As the prevalence of both asthma and obesity is rising, more patients with obese asthma is to be expected. Assessing symptoms, lung function and work ability, and examine whether there is a synergetic effect between asthma and obesity will help understanding this phenotype, ultimately resulting in better treatment of a difficult to treat group of patients with asthma. Further, we aim to assess how occupational exposure influence the different asthma phenotypes. This will generate knowledge on how to follow up exposed patients with asthma. We have collected more detailed data than previous studies on exposure and respiratory health from 16.099 inhabitants in Telemark. In 2018 all these responders and those previously not invited in the same age group (16 to 50 years) were invited, resulting in 12.930 responders. 651 asthma cases and 661 controls underwent medical examination in 2014-2015. Data collection from the follow-up of these are now in progress and 950 subjects are now examined. Working together in an extensive international network and by combining unique data from the Telemark our aim is to give a better understanding of the different asthma phenotypes, a key to better prevention and personalized treatment of asthma.

prosjektdeltakere

prosjektleder

Johny Kongerud

  • Tilknyttet:
    Prosjektleder
    ved Lungeavdelingen ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved Lungeavdeling - HLK ved Oslo universitetssykehus HF

Paul Keefer Henneberger

  • Tilknyttet:
    Prosjektdeltaker
    ved Center for Disease control and prevention

Øystein Lunde Holla

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk serviceklinikk ved Sykehuset Telemark HF

Jens Kristoffer Hertel

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

Geir Klepaker

  • Tilknyttet:
    Prosjektdeltaker
    ved Det medisinske fakultet ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk serviceklinikk ved Sykehuset Telemark HF
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Resultater Resultater

Influence of Obesity on Work ability, Respiratory Symptoms, and Lung Function in Adults with Asthma.

Klepaker, Geir; Svendsen, Martin Veel; Hertel, Jens Kristoffer; Holla, Øystein Lunde; Henneberger, Paul Keefer; Kongerud, Johny; Fell, Anne Kristin Møller. 2019, Respiration. USA, TELEMARK, VESTFOLD, UIO, OUSVitenskapelig artikkel
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