Cristin-prosjekt-ID: 535940
Sist endret: 13. mars 2017 12:02

Cristin-prosjekt-ID: 535940
Sist endret: 13. mars 2017 12:02
Prosjekt

Lab-on-a-chip biofotonisk sensor platform for diagnostikk

prosjektleder

Astrid Aksnes
ved Institutt for elektroniske systemer ved Norges teknisk-naturvitenskapelige universitet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Norges teknisk-naturvitenskapelige universitet

Finansiering

  • TotalbudsjettNOK 34.482.000
  • Norges forskningsråd
    Prosjektkode: 248869/O70

Tidsramme

Aktivt
Start: 1. februar 2017 Slutt: 31. oktober 2020

Beskrivelse Beskrivelse

Tittel

Lab-on-a-chip biofotonisk sensor platform for diagnostikk

Tittel

Lab-on-a-chip biophotonic sensor platform for diagnostics

Vitenskapelig sammendrag

The ultimate goal of this project is to develop a generic lab-on-a-chip (LOC) label-free biophotonic sensor platform capable of performing highly sensitive and selective multiplexed quantitative diagnostic tests. By modifying the surface functionalization of the multiplexed photonic sensing elements, different biomarkers can be detected in parallel with ng/ml - pg/ml limit of detection (LOD). This enables numerous biomedical applications such as diagnosis of cancer and infectious diseases (e.g HIV and tuberculosis).

This proposal combines research efforts in bioengineering, nanofluidics, and nano-photonics to achieve progress beyond the state-of-the-art pushing technology from the lab bench towards a miniaturized LOC sensor platform with potential for mass production. The innovative design of the separately biofunctionalized photonic crystal sensing elements integrated with nanofluidic circuits allows arrays of sensors on a millimeter squared-sized chip to be analyzed in <20 min.

In our choice of biomarkers for the demonstrator, we take advantage of our expertise in immunology and inflammation at St Olavs University Hospital and NTNU. Our demonstrator will include three target biomarkers: Lipocalin 2 (LCN2), c-reactive protein (CRP), and tumour necrosis factor (TNF). CRP is a well-characterized and established biomarker in clinical use and will be used to qualify the performance of the biophotonic sensor platform. TNF is an established marker relevant for monitoring certain inflammatory diseases and also for inflammation research purposes. LCN2 is an antibacterial protein with potential as inflammatory biomarker. LCN2 can be measured in blood serum or plasma, in feces and in urine, and it is currently under development for potential use as a diagnostic marker for kidney failure. 

prosjektdeltakere

prosjektleder

Astrid Aksnes

  • Tilknyttet:
    Prosjektleder
    ved Institutt for elektroniske systemer ved Norges teknisk-naturvitenskapelige universitet

Reinold Ellingsen

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for elektroniske systemer ved Norges teknisk-naturvitenskapelige universitet

Jens Høvik

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for elektroniske systemer ved Norges teknisk-naturvitenskapelige universitet

Dag Roar Hjelme

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for elektroniske systemer ved Norges teknisk-naturvitenskapelige universitet

Øyvind Halaas

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for klinisk og molekylær medisin ved Norges teknisk-naturvitenskapelige universitet
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