Cristin-prosjekt-ID: 540811
Sist endret: 22. september 2017, 13:10

Cristin-prosjekt-ID: 540811
Sist endret: 22. september 2017, 13:10
Prosjekt

Polygenetics of attention and effort: Uncovering brain circuit pathologies in schizophrenia

prosjektleder

Thomas Espeseth
ved Psykologisk institutt ved Universitetet i Oslo

prosjekteier / koordinerende forskningsansvarlig enhet

  • Psykologisk institutt ved Universitetet i Oslo

Finansiering

  • TotalbudsjettNOK 3.500.000
  • Norges forskningsråd
    Prosjektkode: 231286

Klassifisering

Vitenskapsdisipliner

Psykologi

Emneord

Kognitiv nevropsykologi

Kategorier

Prosjektkategori

  • Bidragsprosjekt

Tidsramme

Avsluttet
Start: 1. juni 2014 Slutt: 14. november 2018

Beskrivelse Beskrivelse

Tittel

Polygenetics of attention and effort: Uncovering brain circuit pathologies in schizophrenia

Populærvitenskapelig sammendrag

Schizophrenia is a severe mental disorder with high morbidity, large impact on patients and their families, and huge costs for society and the health care sector globally. Despite progress in genetic, brain imaging, and cognitive research, the biological deficiencies underlying schizophrenia are still mainly unknown. Cognitive abnormalities are key components of schizophrenia, and unlike positive symptoms, including hallucinations and delusions, cognitive symptoms predate diagnosis, predict functional out come, resist treatment, and often persist throughout life. Understanding the biological basis of cognitive abnormalities in schizophrenia, at molecular and brain network levels, will be critically important for the development of treatments that can ameli orate them.

There is strong evidence for a role of brain neuromodulatory systems in attention and learning, especially involving noradrenaline, acetylcholine, and dopamine, but their interaction patterns are less well understood. We hypothesize that an im portant basis of cognitive symptoms in schizophrenia is abnormalities in the brainstem noradrenergic system, and particularly its interaction with dopamine systems and brain control networks. We will take advantage of recent methodological advances to uncover brain circuit malfunctions underlying cognitive abnormalities in schizophrenia. In particular, we will combine new methods from large-scale genetics research with measurements of task-dependent pupil dilations and functional imaging of brain networks that underlie flexible goal-directed behavior. We aim to define a genetic signal that is specific to the biological deficiencies that underlie schizophrenia. Subsequently, we will investigate where in the brain, and when in development, from fetal stages to adulthood, these genetic markers are particularly active.

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Thomas Espeseth

  • Tilknyttet:
    Prosjektleder
    ved Psykologisk institutt ved Universitetet i Oslo

Veronica Exposito

  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo

Samira Aminihajibashi

  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo
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