Cristin-prosjekt-ID: 540873
Sist endret: 19. september 2019, 09:34

Cristin-prosjekt-ID: 540873
Sist endret: 19. september 2019, 09:34
Prosjekt

Secondary prevention of depression applying an experimental Attentional Bias Modification procedure

prosjektleder

Nils Inge Landrø
ved Universitetet i Oslo

prosjekteier / koordinerende forskningsansvarlig enhet

  • Universitetet i Oslo

Finansiering

  • TotalbudsjettNOK 3.900.000
  • Norges forskningsråd
    Prosjektkode: 229135

Tidsramme

Avsluttet
Start: 1. januar 2014 Slutt: 31. juli 2018

Beskrivelse Beskrivelse

Tittel

Secondary prevention of depression applying an experimental Attentional Bias Modification procedure

Populærvitenskapelig sammendrag

A premise for this project is that targeting basic cognitive and neural mechanisms has the potential to translate into new principles for depression treatment and prevention of relapse of depressive episodes. The project is a translational study testing a new computerized method for correcting implicit biases in emotional information processing (Attention Bias Modification; ABM) , a core maintaining factor of recurrence in major depression. This experimental cognitive bias modification has been shown to reduce surrogate markers of depression vulnerability in patients in remission from depression. As such, this approach represents an exciting opportunity for secondary prevention using an acceptable, non-drug intervention. However, recent evidence suggests that such effects tested in the lab may be dependent on candidate genes which affect serotonin reuptake and which have been implicated in malleability and emotional learning. The current study will therefore test the following hypotheses: 1: Attentional bias modification will reduce cognitive, neurobiological and emotional markers of vulnerability in a large sample of patients in remission from major depression. 2: These effects will be modulated by the serotonin transporter genotype. 3: Attentional bias modification will reduce episodes of low mood over a 12 month follow-up period and these effects will be predicted by individual variation in the early effects on surrogate markers. In addition, the project will explore the neural changes brought about by ABM in patients vulnerable to depression using models of emotion regulation

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Nils Inge Landrø

  • Tilknyttet:
    Prosjektleder
    ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo

Catherine Harmer

  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved University of Oxford

Brage Kraft

  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo

Eva Hilland

  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo

Luigi Maglanoc

  • Tilknyttet:
    Prosjektdeltaker
    ved Psykologisk institutt ved Universitetet i Oslo
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Resultater Resultater

Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial.

Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Browning, Michael; Maglanoc, Luigi Angelo; Jonassen, Rune. 2019, Journal of Psychiatry & Neuroscience. UoO, DIAKONSYK, UIO, AHUS, OUSVitenskapelig artikkel

Effects of Attentional Bias Modification on residual symptoms in depression: A randomized controlled trial.

Jonassen, Rune; Harmer, Catherine; Hilland, Eva; Maglanoc, Luigi Angelo; Kraft, Brage; Browning, Michael; Stiles, Tore C; Haaland, Vegard Øksendal; Berge, Torkil; Landrø, Nils Inge. 2019, BMC Psychiatry. OUH, UoO, DIAKONSYK, NTNU, UIO, SØRLAND, OUSVitenskapelig artikkel

Within-network connectivity in the salience network after attention bias modification training in residual depression: Report from a preregistered clinical trial.

Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Maglanoc, Luigi Angelo; Jonassen, Rune. 2018, Frontiers in Human Neuroscience. UoO, DIAKONSYK, OSLOMET, UIO, OUSVitenskapelig artikkel

Attention Bias Modification in Remitted Depression Is Associated With Increased Interest and Leads to Reduced Adverse Impact of Anxiety Symptoms and Negative Cognition.

Kraft, Brage; Jonassen, Rune; Heeren, Alexandre; Harmer, Catherine; Stiles, Tore C; Landrø, Nils Inge. 2019, Clinical Psychological Science. UoO, DIAKONSYK, NTNU, UIO, AHUS, UCLVitenskapelig artikkel

A Prospective Test of the Metacognitive Model of Depression in Previously Depressed Individuals.

Kraft, Brage; Jonassen, Rune; Ulset, Vidar; Stiles, Tore C; Landrø, Nils Inge. 2019, Cognitive Therapy and Research. DIAKONSYK, OSLOMET, NTNU, UIOVitenskapelig artikkel
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