Cristin-prosjekt-ID: 554110
Sist endret: 26. september 2017 14:53
Cristin-prosjekt-ID: 554110
Sist endret: 26. september 2017 14:53
Prosjekt

Evolution and spread of high-level beta-lactam resistance in Haemophilus influenzae

prosjektleder

Dagfinn Skaare
ved Sykehuset i Vestfold HF

prosjekteier / koordinerende forskningsansvarlig enhet

  • Sykehuset i Vestfold HF

Finansiering

  • Helse Sør-Øst RHF

Klassifisering

Vitenskapsdisipliner

Medisinsk mikrobiologi

Emneord

Antibiotikaresistens

HRCS-helsekategori

  • Infeksjon

Kategorier

Prosjektkategori

  • Grunnforskning

Tidsramme

Aktivt
Start: 1. januar 2017 Slutt: 31. desember 2020

Beskrivelse Beskrivelse

Tittel

Evolution and spread of high-level beta-lactam resistance in Haemophilus influenzae

Vitenskapelig sammendrag

Resistance to antibiotics is an emerging threat to global health care, and immediate action on global, regional, national and local levels is necessary to preserve effective antibiotics for the future. In a global action plan on antimicrobial resistance presented by WHO in May 2015, one of five objectives is "to strengthen the knowledge and evidence base through surveillance and research" . According to a recent review on antimicrobial resistance, 700.000 deaths every year are caused by infections with resistant bacteria, and without policies to stop the spread of resistant bacteria the number is assumed to rise to 10 million every year in 2050. The Norwegian Government issued a strategy to fight antibiotic resistance in Norway in June 2015, and the Norwegian Directory of Health launched an action plan in January 2016. One of the four major objectives of the Norwegian national strategy is to increase our knowledge about drivers and mechanisms of evolution and spread of antibiotic resistance.

Dissemination of Haemophilus influenzae with resistance to extended-spectrum cephalosporins (hereafter denoted high-level beta-lactam resistance) represents a threat to current recommendations for empiric therapy. The development calls for immediate action in terms of intensified surveillance and establishment of harmonized global systems for characterization and mapping of resistant clones. Also, the mechanisms by which high-level beta-lactam resistance evolves in H. influenzae are incompletely understood, and more research to elucidate resistance development at a molecular level and to identify drivers of resistance in this organism is urgently needed.

As a consequence of this situation, we plan to start a new research project at the Department of Microbiology, Vestfold Hospital Trust (Figure 1A and 1B). The primary objective is to determine the mechanisms for evolution, spread and persistence of high-level beta-lactam resistance in H. influenzae. This will be performed by characterization of a large, unique collection of Norwegian H. influenzae strains with high-level beta-lactam resistance (2006-2016) using state-of-the-art methods, including whole-genome sequencing and phenotypic susceptibility testing with reference methodology, in order to map the dissemination of resistant clones, and perform in vitro mutagenesis experiments and fitness studies to explore the mechanisms by which resistance evolves, spreads and persists. This is an important first step to develop novel intervention strategies to prevent the spread of resistant H. influenzae and to ensure safe antimicrobial therapy in severe infections caused by this organism.

 

prosjektdeltakere

prosjektleder

Dagfinn Skaare

  • Tilknyttet:
    Prosjektleder
    ved Sykehuset i Vestfold HF

Martin Steinbakk

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Dominique A Caugant

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Kristin Hegstad

  • Tilknyttet:
    Prosjektdeltaker
    ved UiT Norges arktiske universitet

Arnfinn Sundsfjord

  • Tilknyttet:
    Prosjektdeltaker
    ved UiT Norges arktiske universitet
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