Cristin-prosjekt-ID: 607802
Sist endret: 22. august 2018 14:30
Cristin-prosjekt-ID: 607802
Sist endret: 22. august 2018 14:30
Prosjekt

Development of a rapid serological screening test for TB (TBRT project)

prosjektleder

Carol J C Holm-Hansen
ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Folkehelseinstituttet

Finansiering

  • TotalbudsjettNOK 13.500.000
  • Norges forskningsråd

  • Universitetet i Oslo

Kontaktinformasjon

Sted
Carol Holm-Hansen

Tidsramme

Avsluttet
Start: 1. juni 2009 Slutt: 30. september 2018

Beskrivelse Beskrivelse

Tittel

Development of a rapid serological screening test for TB (TBRT project)

Populærvitenskapelig sammendrag

A rapid serological screening method for detecting tuberculosis disease and monitoring the efficacy of new vaccines

The development of new diagnostic tools and more effective vaccines are essential to combat the global tuberculosis (TB) pandemic. The lack of a widely accessible screening test that is easy to perform without laboratory facilities is one of the main reasons for the unacceptable delay in diagnosing pulmonary TB. The goal of this project is to develop, evaluate and validate a rapid, sensitive and inexpensive serological test for the detection of TB disease that is suitable for use in the developing world.

 

It is crucial that a screening test detects only active disease because latent TB is prevalent, but not a target for treatment, in developing countries. Recent advances in proteomics and genomics make it possible to investigate a large repertoire of M. tuberculosis proteins for their ability to serve as diagnostic markers. Comparison of antigens recognized by antibodies from patients and community controls recruited from TB endemic regions will enable the identification of appropriate antigens that can be used to differentiate between active and latent infection. After demonstrating proof-of-principle the prototype ELISA assay will be transferred to a rapid assay platform and evaluated in the field by collaborative partners in settings with different TB epidemiology.  

 

A rapid screening test will make it possible to identify and selectively treat those with active TB disease at the local health care level thus reducing diagnostic delay and transmission. In addition, the test will be designed to differentiate between TB and vaccine-induced immunity. Accurate diagnostic tools suitable for use in the developing world are essential for monitoring the efficacy of new candidate TB vaccines. The collaborative network and administrative structure of this project are designed to achieve ideal cross-institutional interactions between Western and developing countries, technology transfer, decentralization and increasing local capacity to curb TB in endemic regions.

prosjektdeltakere

prosjektleder

Carol J C Holm-Hansen

  • Tilknyttet:
    Prosjektleder
    ved Avdeling for infeksjonsimmunologi ved Folkehelseinstituttet

Nick Borain

  • Tilknyttet:
    Prosjektdeltaker
    ved Sør-Afrika

Elena Hailu

  • Tilknyttet:
    Prosjektdeltaker
    ved AHRI Armauer Hansen Research Institute

Shiferaw Bekele

  • Tilknyttet:
    Prosjektdeltaker
    ved AHRI Armauer Hansen Research Institute

Markos Abebe

  • Tilknyttet:
    Prosjektdeltaker
    ved AHRI Armauer Hansen Research Institute
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Resultater Resultater

Nε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 strains: Proteins Involved in Bioenergetics, Virulence and Antimicrobial Resistance are Acetylated.

Birhanu, Alemayehu Godana; Solomon, Abebe Yimer; Holm-Hansen, Carol J C; Norheim, Gunnstein; Aseffa, Abraham; Abebe, Markose; Tonjum, Tone. 2017, Journal of Proteome Research. AHRI, AAU, FHI, UIO, OUSVitenskapelig artikkel

Comparative proteomic analysis of Mycobacterium tuberculosis lineage 7 and lineage 4 strains reveals differentially abundant proteins linked to slow growth and virulence.

Yimer, Solomon Abebe; Birhanu, Alemayehu Godana; Kalayou, Shewit; Riaz, Tahira; Zegeye, Ephrem Debebe; Beyene, Getachew Tesfaye; Holm-Hansen, Carol J C; Norheim, Gunnstein; Abebe, Markose; Aseffa, Abraham mfl.. 2017, Frontiers in Microbiology. AHRI, NORCE, AAU, FHI, UIO, OUSVitenskapelig artikkel

First proteomic analysis of Mycobacterium tuberculosis lineage 7 differentially expressed proteins involved for growth.

Yimer, Solomon Abebe; Birhanu, Alemayehu Godana; Shewit, Kalayou; Riaz, Tahira; Zegeye, Ephrem Debebe; Beyene, Getachew Tesfaye; Holm-Hansen, Carol J C; Norheim, Gunnstein; Abebe, Markos; Aseffa, Abraham mfl.. 2016, 47th Union World Conference on Lung Health. FHI, UIOFaglig foredrag

Deciphering the recent phylogenetic expansion of the originally deeply rooted Mycobacterium tuberculosis lineage 7.

Yimer, Solomon Abebe; Namouchi, Amine; Zegeye, Ephrem Debebe; Holm-Hansen, Carol J C; Norheim, Gunnstein; Abebe, Markos; Aseffa, Abraham; Tonjum, Tone. 2016, BMC Evolutionary Biology. AHRI, NORCE, FHI, UIO, OUSVitenskapelig artikkel

Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: ‘Aethiops vetus’.

Nebenzahl-Guimaraes, Hanna; Yimer, Solomon Abebe; Holm-Hansen, Carol J C; de Beer, Jessica; Brosch, Roland; van Soolingen, Dick. 2016, Microbial Genomics. UMCN, FHI, PASTEUR, RIVM, OUSVitenskapelig artikkel
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