Every year, more than 3000 Norwegian women undergo breast cancer surgery. More than 40% of them will struggle with pain and fatigue years after surgery, regardless of surgical procedure. These consequences are detrimental and result in distress and disability, including work disability. We do not have an effective way of preventing these conditions from developing, nor do we have adequate treatment options when the symptoms persist. No previous attempts have been made to prevent persistent pain and fatigue after surgery by applying a psychological approach, despite psychological risk factors being crucial in the development of both persistent pain and fatigue. To alleviate acute post-surgical pain and fatigue, hypnosis is a harmless and promising intervention. A recent study demonstrated large effects of a brief pre-operative hypnosis on analgesic needs, pain intensity and fatigue after breast cancer surgery, but these results have not been replicated, and results from hypnosis trials in general lack long-term follow-up.