Sammendrag
The Norwegian Health Care system significantly diffe
rs from international setti
ngs such as the U.S.,
where the majority of research on pregnant opio
id dependent women is conducted. Hence results
from international research may not be generalized to
the Norwegian setting. Therefore, to be able
to offer the best possible care, it
is of great importance to investigate how pregnant women in opioid
maintenance treatment (OMT) in Norway are farin
g in regards to continued substance use and
psychiatric problems both during pregnancy and so
metime after the children are born. Secondly, the
partners of pregnant opioid de
pendent women may contribute to the woman’s drug use relapses as
well as to improved treatment outcomes and how th
e woman will cope as a mother. However, they
are rarely included in studies on pregnant opioid
dependent women. Moreover, there is a lack of
studies offering a compete overview of use of pres
cription drug use prior to, and during pregnancy
among OMT women. Lastly, maternal and neonatal
outcomes after exposure to buprenorphine +
naloxone has not been compared to other medici
nal treatments for opioid dependence such as
buprenorphine, methadone and meth
adone assisted withdrawal. Despite the lack of research on
this, buprenorphine + naloxone is prescribed to pr
egnant opioid dependent women several places in
the U.S.
Study aims
The aims of the present thesis were to investig
ate substance abuse and psychiatric problems in a
national cohort of pregnant OMT women and their partners. Moreover, to investigate use of
prescription drugs among women in OMT prio
r to, and during pregnancy. Furthermore, to
investigate maternal and neonatal outcomes from use of buprenorphine + naloxone versus
methadone, buprenorphine and methadone-assisted withdrawa
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