Cristin-resultat-ID: 1042391
Sist endret: 1. desember 2013, 15:20
NVI-rapporteringsår: 2013
Resultat
Vitenskapelig artikkel
2013

Neurocognitive development in first episode psychosis 5 years follow-up: associations between illness severity and cognitive course

Bidragsytere:
  • Helene Barder
  • Kjetil Søren Sundet
  • Bjørn Rishovd Rund
  • Julie Horgen Evensen
  • Ulrik Haahr
  • Wenche Hegelstad
  • mfl.

Tidsskrift

Schizophrenia Research
ISSN 0920-9964
e-ISSN 1573-2509
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2013
Volum: 149
Hefte: 1-3
Sider: 63 - 69

Importkilder

Isi-ID: 000323937200009
Scopus-ID: 2-s2.0-84881255693

Klassifisering

Vitenskapsdisipliner

Psykiatri, barnepsykiatri

Beskrivelse Beskrivelse

Tittel

Neurocognitive development in first episode psychosis 5 years follow-up: associations between illness severity and cognitive course

Sammendrag

Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood. The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years. Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity, Motor Speed, and Working Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively. Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years. Motor Speed decreased significantly from 2 to 5 years. Number of relapses was significantly related to Verbal Learning and Working Memory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group. Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding how psychotic illnesses progress, is the finding of significant associations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.

Bidragsytere

Helene Barder

  • Tilknyttet:
    Forfatter
    ved Psykoseforskning, seksjon (NORMENT/KG Jebsen OUS) ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Klinikk psykisk helse og avhengighet ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Psykologisk institutt ved Universitetet i Oslo
Aktiv cristin-person

Kjetil Søren Sundet

  • Tilknyttet:
    Forfatter
    ved Psykologisk institutt ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Klinikk psykisk helse og avhengighet ved Oslo universitetssykehus HF
Aktiv cristin-person

Bjørn Rishovd Rund

  • Tilknyttet:
    Forfatter
    ved Forskningsenheten ved Vestre Viken HF
  • Tilknyttet:
    Forfatter
    ved Psykologisk institutt ved Universitetet i Oslo

Julie Horgen Evensen

  • Tilknyttet:
    Forfatter
    ved Klinikk psykisk helse og avhengighet ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Klinikk psykisk helse og avhengighet ved Universitetet i Oslo

Ulrik Haahr

  • Tilknyttet:
    Forfatter
    ved Psykiatrisk Forskningsenhed - Region Sjælland
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