Cristin-resultat-ID: 1045338
Sist endret: 25. oktober 2016 14:33
NVI-rapporteringsår: 2013
Resultat
Vitenskapelig artikkel
2014

The occurrence of polycyclic aromatic hydrocarbons and their derivatives and the proinflammatory potential of fractionated extracts of diesel exhaust and wood smoke particles

Bidragsytere:
  • Annike Irene Totlandsdal
  • Johan Øvrevik
  • Richard Cocheran
  • Jan Inge Herseth
  • Anette Kocbach Bølling
  • Marit Låg
  • mfl.

Tidsskrift

Journal of Environmental Science and Health. Part A: Toxic/Hazardous Substances and Environmental Engineering
ISSN 1093-4529
e-ISSN 1532-4117
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2014
Publisert online: 2013
Trykket: 2014
Volum: 49
Hefte: 4
Sider: 383 - 396
Open Access

Importkilder

Scopus-ID: 2-s2.0-84890830015

Klassifisering

Vitenskapsdisipliner

Toksikologi

Beskrivelse Beskrivelse

Tittel

The occurrence of polycyclic aromatic hydrocarbons and their derivatives and the proinflammatory potential of fractionated extracts of diesel exhaust and wood smoke particles

Sammendrag

Exposure to combustion emissions, including diesel engine exhaust and wood smoke particles (DEPs and WSPs), has been associated with inflammatory responses. To investigate the possible role of polycyclic aromatic hydrocarbons (PAHs) and PAH-derivatives, the DEPs and WSPs methanol extracts were fractionated by solid phase extraction (SPE), and the fractions were analyzed for more than ~120 compounds. The pro-inflammatory effects of the fractionated extracts were characterized by exposure of bronchial epithelial lung cells (BEAS-2B). Both native DEPs and WSPs caused a concentration-dependent increase in IL-6 and IL-8 release and cytotoxicity. This is consistent with the finding of a rather similar total content of PAHs and PAH-derivatives. Yet, the samples differed in specific components, suggesting that different species contribute to the toxicological response in these two types of particles. The majority of the IL-6 release and cytotoxicity was induced upon exposure to the most polar (methanol) SPE fraction of extracts from both samples. In these fractions hydroxy-PAHs, carboxy-PAHs were observed along with nitro-amino-PAHs in DEP. However, the biological effects induced by the polar fractions could not be attributed only to the occurrence of PAH-derivatives. The present findings indicate a need for further characterization of organic extracts, beyond an extensive analysis of commonly suspected PAH and PAH-derivatives.

Bidragsytere

Annike Irene Totlandsdal

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Johan Øvrevik

  • Tilknyttet:
    Forfatter
    ved Avdeling for luft og støy ved Folkehelseinstituttet

Richard Cocheran

  • Tilknyttet:
    Forfatter
    ved University of North Dakota

Jan Inge Herseth

  • Tilknyttet:
    Forfatter
    ved Institutt for naturvitenskapelige helsefag ved OsloMet - storbyuniversitetet

Anette Kocbach Bølling

  • Tilknyttet:
    Forfatter
    ved Avdeling for luft og støy ved Folkehelseinstituttet
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