Cristin-resultat-ID: 1059373
Sist endret: 25. oktober 2016, 14:33
NVI-rapporteringsår: 2013
Vitenskapelig artikkel

Carbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses

  • Unni Cecilie Nygaard
  • Mari Samuelsen
  • Calin Daniel Marioara og
  • Martinus Løvik


BioMed Research International
ISSN 2314-6133
e-ISSN 2314-6141
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2013
Volum: 2013
Artikkelnummer: 476010
Open Access


Isi-ID: 000323978600001
Scopus-ID: 2-s2.0-84884220583



Medisinsk immunologi

Beskrivelse Beskrivelse


Carbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses


There is a growing concern for the possible health impact of nanoparticles. The main objective of this study was to investigate the allergy-promoting capacity of four different carbon nanofiber (CNF) samples in an injection and an airway mouse model of allergy. Secondly, the potency of the CNF was compared to the previously reported allergy-promoting capacity of carbon nanotubes (CNT) in the airway model. Ultrafine carbon black particles (ufCBP) were used as a positive control. Particles were given together with the allergen ovalbumin (OVA) either by subcutaneous injection into the footpad or intranasally to BALB/cA mice. After allergen booster, OVA-specific IgE, IgG1, and IgG2a in serum were measured. In the airway model, inflammation was determined as influx of inflammatory cells (eosinophils, neutrophils, lymphocytes, and macrophages) and by mediators (MCP-1 and TNF- present in bronchoalveolar fluid (BALF)). CNF and CNT both increased OVA-specific IgE levels in the two models, but in the airway model, the CNT gave a significantly stronger IgE response than the CNF. Furthermore, the CNT and not the CNF promoted eosinophil lung inflammation. Our data therefore suggest that nanotube-associated properties are particularly potent in promoting allergic responses.


Unni Cecilie Nygaard

  • Tilknyttet:
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

Mari Samuelsen

  • Tilknyttet:
    ved Folkehelseinstituttet

Calin Daniel Marioara

  • Tilknyttet:
    ved Materialer og nanoteknologi ved SINTEF AS

Martinus Løvik

  • Tilknyttet:
    ved Institutt for klinisk og molekylær medisin ved Norges teknisk-naturvitenskapelige universitet
  • Tilknyttet:
    ved Folkehelseinstituttet
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