Cristin-resultat-ID: 1059373
Sist endret: 25. oktober 2016 14:33
NVI-rapporteringsår: 2013
Resultat
Vitenskapelig artikkel
2013

Carbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses

Bidragsytere:
  • Unni Cecilie Nygaard
  • Mari Samuelsen
  • Calin Daniel Marioara og
  • Martinus Løvik

Tidsskrift

BioMed Research International
ISSN 2314-6133
e-ISSN 2314-6141
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2013
Volum: 2013
Artikkelnummer: 476010
Open Access

Importkilder

Isi-ID: 000323978600001

Klassifisering

Vitenskapsdisipliner

Medisinsk immunologi

Beskrivelse Beskrivelse

Tittel

Carbon nanofibers have IgE adjuvant capacity but are less potent than nanotubes in promoting allergic airway responses

Sammendrag

There is a growing concern for the possible health impact of nanoparticles. The main objective of this study was to investigate the allergy-promoting capacity of four different carbon nanofiber (CNF) samples in an injection and an airway mouse model of allergy. Secondly, the potency of the CNF was compared to the previously reported allergy-promoting capacity of carbon nanotubes (CNT) in the airway model. Ultrafine carbon black particles (ufCBP) were used as a positive control. Particles were given together with the allergen ovalbumin (OVA) either by subcutaneous injection into the footpad or intranasally to BALB/cA mice. After allergen booster, OVA-specific IgE, IgG1, and IgG2a in serum were measured. In the airway model, inflammation was determined as influx of inflammatory cells (eosinophils, neutrophils, lymphocytes, and macrophages) and by mediators (MCP-1 and TNF- present in bronchoalveolar fluid (BALF)). CNF and CNT both increased OVA-specific IgE levels in the two models, but in the airway model, the CNT gave a significantly stronger IgE response than the CNF. Furthermore, the CNT and not the CNF promoted eosinophil lung inflammation. Our data therefore suggest that nanotube-associated properties are particularly potent in promoting allergic responses.

Bidragsytere

Unni Cecilie Nygaard

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

Mari Samuelsen

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Calin Daniel Marioara

  • Tilknyttet:
    Forfatter
    ved Materialer og nanoteknologi ved SINTEF AS

Martinus Løvik

  • Tilknyttet:
    Forfatter
    ved Institutt for klinisk og molekylær medisin ved Norges teknisk-naturvitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet
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