Cristin-resultat-ID: 1141280
Sist endret: 28. november 2017, 10:56
NVI-rapporteringsår: 2014
Resultat
Vitenskapelig artikkel
2014

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

Bidragsytere:
  • Stian Ellefsen
  • Olav Vikmoen
  • Gunnar Slettaløkken
  • Jon Elling Whist
  • Håvard Nygård
  • Ivana Hollan
  • mfl.

Tidsskrift

European Journal of Applied Physiology
ISSN 1439-6319
e-ISSN 1439-6327
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2014
Trykket: 2014
Volum: 114
Hefte: 9
Sider: 1875 - 1888

Importkilder

Scopus-ID: 2-s2.0-84901737135
Scopus-ID: 2-s2.0-85027945820

Beskrivelse Beskrivelse

Tittel

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

Sammendrag

Purpose: To investigate the effects of strength training on abundances of irisin-related biomarkers in skeletal muscle and blood of untrained young women, and their associations with body mass composition, muscle phenotype and levels of thyroid hormones. Methods: Eighteen untrained women performed 12 weeks of progressive whole-body heavy strength training, with measurement of strength, body composition, expression of irisin-related genes (FNDC5 and PGC1α) in two different skeletal muscles, and levels of serum-irisin and -thyroid hormones, before and after the training intervention. Results: The strength training intervention did not result in changes in serum-irisin or muscle FNDC5 expression, despite considerable effects on strength, lean body mass (LBM) and skeletal muscle phenotype. Our data indicate that training affects irisin biology in a LBM-dependent manner. However, no association was found between steady-state serum-irisin or training-associated changes in serum-irisin and alterations in body composition. FNDC5 expression was higher in m.Biceps brachii than in m.Vastus lateralis, with individual expression levels being closely correlated, suggesting a systemic mode of transcriptional regulation. In pre-biopsies, FNDC5 expression was correlated with proportions of aerobic muscle fibers, a relationship that disappeared in post-biopsies. No association was found between serum-thyroid hormones and FNDC5 expression or serum-irisin. Conclusion: No evidence was found for an effect of strength training on irisin biology in untrained women, though indications were found for a complex interrelationship between irisin, body mass composition and muscle phenotype. FNDC5 expression was closely associated with muscle fiber composition in untrained muscle.

Bidragsytere

Aktiv cristin-person

Stian Ellefsen

  • Tilknyttet:
    Forfatter
    ved Institutt for folkehelse- og idrettsvitenskap ved Høgskolen i Innlandet
Aktiv cristin-person

Olav Vikmoen

  • Tilknyttet:
    Forfatter
    ved Fakultet for helse- og sosialvitenskap ved Høgskolen i Innlandet

Gunnar Slettaløkken

  • Tilknyttet:
    Forfatter
    ved Institutt for folkehelse- og idrettsvitenskap ved Høgskolen i Innlandet

Jon Elling Whist

  • Tilknyttet:
    Forfatter
    ved Div Medisinsk service ved Sykehuset Innlandet HF
Aktiv cristin-person

Håvard Nygård

  • Tilknyttet:
    Forfatter
    ved Institutt for folkehelse- og idrettsvitenskap ved Høgskolen i Innlandet
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