Cristin-resultat-ID: 1149213
Sist endret: 28. oktober 2016 16:37
NVI-rapporteringsår: 2014
Resultat
Vitenskapelig artikkel
2014

Passive smoking assessed by salivary cotinine and self-report in relation to cause-specific mortality: 17-year follow-up of study participants in the UK Health and Lifestyle Survey

Bidragsytere:
  • G. David Batty
  • Catherine M. Gale
  • Barbara Jefferis og
  • Elisabeth Kvaavik

Tidsskrift

Journal of Epidemiology and Community Health
ISSN 0143-005X
e-ISSN 1470-2738
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2014
Publisert online: 2014
Volum: 68
Hefte: 12
Sider: 1200 - 1203

Importkilder

Scopus-ID: 2-s2.0-84911399849

Beskrivelse Beskrivelse

Tittel

Passive smoking assessed by salivary cotinine and self-report in relation to cause-specific mortality: 17-year follow-up of study participants in the UK Health and Lifestyle Survey

Sammendrag

Evidence that passive smoking is a risk factor for cardiovascular disease and selected cancers is largely derived from studies in which this exposure is self-reported. Objective assessment using biochemical techniques may yield a more accurate estimate of risk, although each approach has its strengths and weaknesses. We examined the association of salivary cotinine, a widely utilised biomarker for passive smoking, and self-reported passive smoking in the home, with mortality from all causes, cardiovascular disease and all cancers combined. In 1992, investigators on the UK Health and Lifestyle Survey collected data on salivary cotinine, self-reported smoking (direct and passive) and a range of covariates in 3731 men and women aged 25 years and over. Mortality was ascertained using linkage to national death records. Analyses were based on 2523 individuals (1433 [57%] women) who classified themselves as non-smokers (never and former). Seventeen years of follow-up gave rise to 588 deaths (253 from cardiovascular disease and 146 from cancer). In men, adjusted hazard ratios (HR) for the association between cotinine levels (1.3-15.0 [high] vs ≤0.3 [low] ng/mL) and the various mortality outcomes were weak for total mortality (HR; 95% CI: 1.22; 0.91 to 1.64) and cardiovascular disease (1.25; 0.78 to 1.99) and absent for all cancers combined (1.10; 0.61 to 2.00). Corresponding associations were generally stronger when self-reported passive smoking (some vs none) was the exposure of interest: 1.53 (1.12 to 2.08), 1.88 (1.20 to 2.96) and 1.58 (0.85 to 2.93). The pattern of association for women in both sets of analyses was less consistent. In men in the present study, compared with our biochemical marker of passive smoking, cotinine, mortality was generally more consistently associated with self-reported passive smoking.

Bidragsytere

G. David Batty

  • Tilknyttet:
    Forfatter
    ved The University of Edinburgh
  • Tilknyttet:
    Forfatter
    ved University College London

Catherine M. Gale

  • Tilknyttet:
    Forfatter
    ved The University of Edinburgh

Barbara Jefferis

  • Tilknyttet:
    Forfatter
    ved University of Southampton
Aktiv cristin-person

Elisabeth Kvaavik

  • Tilknyttet:
    Forfatter
    ved Avdeling for rusmidler og tobakk ved Folkehelseinstituttet
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