Cristin-resultat-ID: 1152461
Sist endret: 25. oktober 2016 14:33
NVI-rapporteringsår: 2014
Resultat
Vitenskapelig artikkel
2014

Effect of withholding breastfeeding on the immune response to a live oral rotavirus vaccine in North Indian infants

Bidragsytere:
  • Temsunaro Rongsen-Chandola
  • Tor Strand
  • Nidhi Goyal
  • Elmira Flem
  • Sudeep Singh Rathore
  • Alok Arya
  • mfl.

Tidsskrift

Vaccine
ISSN 0264-410X
e-ISSN 1873-2518
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2014
Volum: 32
Sider: A134 - A139
Open Access

Importkilder

Scopus-ID: 2-s2.0-84905190311

Klassifisering

Vitenskapsdisipliner

Samfunnsmedisin, sosialmedisin • Forebyggende medisin • Medisinsk immunologi • Helsetjeneste- og helseadministrasjonsforskning

Finansiering

  • Norges forskningsråd
    Prosjektkode: 223269

Beskrivelse Beskrivelse

Tittel

Effect of withholding breastfeeding on the immune response to a live oral rotavirus vaccine in North Indian infants

Sammendrag

Abstract: Interference from transplacental and breast milk antibodies may impede the performance of oral live vaccines. The effect of breastfeeding on the immunogenicity of Rotarix®, a two-dose oral monovalent rotavirus vaccine, was examined in a community-based trial in New Delhi, India. Four hundred mother–infant pairs were randomized into two equal groups. Infants were aged 6–7 weeks at enrollment. Mothers were encouraged to either breastfeed or to withhold breastfeeding during the 30 min prior to and after each vaccine dose was administered. We collected blood specimens from infants at enrollment and 4 weeks after the second vaccine dose. Blood and breast milk specimens were obtained from mothers at baseline and breast milk specimens were collected at the time of the second vaccine dose. Seroconversion was defined as infant serum anti-VP6 IgA antibody level of ≥20 IU/mL 4 weeks after the second vaccine dose and a ≥4-fold rise from baseline. There was no difference in the proportion who seroconverted between the two groups (26% vs 27%; p = 0.92). The levels of infant serum IgA, maternal serum and breast milk IgA and IgG anti-rotavirus antibodies predicted the anti-rotavirus IgA level in infants at end-study and explained approximately 10% of the variability of the immune response (r2 = 0.10, p

Bidragsytere

Temsunaro Rongsen-Chandola

  • Tilknyttet:
    Forfatter
    ved Society for Applied Studies

Tor A Strand

Bidragsyterens navn vises på dette resultatet som Tor Strand
  • Tilknyttet:
    Forfatter
    ved Div Medisinsk service ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Senter for internasjonal helse ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Institutt for global helse og samfunnsmedisin ved Universitetet i Bergen

Nidhi Goyal

  • Tilknyttet:
    Forfatter
    ved Society for Applied Studies

Elmira Flem

  • Tilknyttet:
    Forfatter
    ved Avdeling for infeksjonsepidemiologi og modellering ved Folkehelseinstituttet

Sudeep Singh Rathore

  • Tilknyttet:
    Forfatter
    ved Society for Applied Studies
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