Cristin-resultat-ID: 1178293
Sist endret: 2. juni 2017 13:34
Resultat
Poster
2014

Development and validation of method for determination of iodine in urine from a mother and child cohort study using triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS QQQ)

Bidragsytere:
  • Linn Katrin Nødland
  • Karl Andreas Jensen
  • Helle Margrete Meltzer og
  • Elin Lovise Gjengedal

Presentasjon

Navn på arrangementet: Nordic Environmental Chemistry Conference (NECC 2014)
Sted: Reykjavik
Dato fra: 11. juni 2014
Dato til: 13. juni 2014

Om resultatet

Poster
Publiseringsår: 2014

Beskrivelse Beskrivelse

Tittel

Development and validation of method for determination of iodine in urine from a mother and child cohort study using triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS QQQ)

Sammendrag

Intake of sufficient amounts of iodine (I) through the diet is essential to prevent iodine deficiency disorders (IDD). Iodine is essential for all metabolic processes in the body and the physiological and neurological development of the fetus and child. Salt iodization is the main strategy for the control of IDD worldwide (WHO & UNICEF 2007). However, in Norway, milk and dairy products, and fish and seafood contributes approximately 80 % of the dietary iodine intake in adults and children (Dahl et al. 2004). The contribution of iodized salt is considered to be insignificant. Sufficient intake of iodine is particularly important for children, which is in the early phase of growth and development, and also for pregnant women as they provide for the fetus. Today, programs for monitoring iodine levels are implemented in most countries to control both IDD and disorders due to excessive iodine intake. Micronutrients, like iodine, are present at variable and often low concentrations in clinical sample types, like urine. Thus, the first aim of the study was to develop a method to get a limit of quantification below 3 μg/L with an uncertainty of less than 10 %. It was also desirable that the working range was linear over a wide area of concentrations as it was expected that the levels of iodine varied a lot from one person to another and also from day to day depending on their diet. Validation parameters that have been determined are linearity, working range, accuracy, precision, robustness, uncertainty, limit of detection (LOD), and limit of quantification (LOQ). The other aim of the study was to identify the levels of iodine in urine from mothers and their children in the area of Oslo and Akershus in Norway. This is of particular interest because these subgroups of the population are at risk of a too low iodine intake, while data on urinary iodine concentration (UIC) in Norwegian children are missing. The urine samples (n=104) were collected by the Norwegian Institute of Public Health (NIPH), pretreated with an alkaline solution containing ammonia, EDTA, 2-propanol, and Triton X-100, and then analyzed for iodine by ICP-MS with an octopole based collision-reaction cell. The mothers and children also registered their 24-hour food intake as well as smoking habits to investigate their impacts on the levels of iodine. Results from ongoing laboratory work will be presented. References Dahl, L., Johansson, L., Julshamn, K. & Meltzer, H. M. (2004). The iodine content of Norwegian foods and diets. Public Health Nutrition, 7 (4): 569-576. WHO & UNICEF. (2007). Iodine Deficiency in Europe - a continuing public health problem. In Andersson, M., de Benoist, B., Darnton-Hill, I. & Delange, F. (eds), 978 92 4 159396 0. Geneva, Switzerland: World Health Organization. 70 pp.

Bidragsytere

Linn Katrin Nødland

  • Tilknyttet:
    Forfatter
    ved Handelshøgskolen ved Norges miljø- og biovitenskapelige universitet

Karl Andreas Jensen

  • Tilknyttet:
    Forfatter
    ved Miljøvitenskap og naturforvaltning ved Norges miljø- og biovitenskapelige universitet

Helle Margrete Meltzer

  • Tilknyttet:
    Forfatter
    ved Smittevern, miljø og helse ved Folkehelseinstituttet

Elin Lovise Folven Gjengedal

Bidragsyterens navn vises på dette resultatet som Elin Lovise Gjengedal
  • Tilknyttet:
    Forfatter
    ved Miljøvitenskap og naturforvaltning ved Norges miljø- og biovitenskapelige universitet
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