Cristin-resultat-ID: 1193677
Sist endret: 1. april 2016 10:49
NVI-rapporteringsår: 2015
Resultat
Vitenskapelig oversiktsartikkel/review
2015

The place of and evidence for Serotonin reuptake inhibitors (SRIs) in obsessive compulsive disorder (OCD) in children and adolescents: views based on a systematic review and meta-analysis

Bidragsytere:
  • Tord Ivarsson
  • Gudmundur Águst Skarphedinsson
  • Hege Kornør
  • Brynhildur Axelsdottir
  • Sølvi Biedilæ
  • Isobel Heyman
  • mfl.

Tidsskrift

Psychiatry Research
ISSN 0165-1781
e-ISSN 1872-7123
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2015
Publisert online: 2014
Trykket: 2015
Volum: 227
Hefte: 1
Sider: 93 - 103

Beskrivelse Beskrivelse

Tittel

The place of and evidence for Serotonin reuptake inhibitors (SRIs) in obsessive compulsive disorder (OCD) in children and adolescents: views based on a systematic review and meta-analysis

Sammendrag

Serotonin reuptake inhibiting drugs (SRI) have been used in the treatment of paediatric obsessive compulsive disorder over the past thirty years. We performed a systematic review and meta-analysis of the literature to discuss the place of and evidence for the use of SRI in pediatric OCD, based on fourteen publications of methodologically sound, randomized and controlled studies. Both SRI and specific SRIs were examined and comparisons of SRI, placebo, cognitive behaviour therapy (CBT), combined (COMBO) treatments (SRI+CBT) made to investigate their relative efficacy. Using the Cochrane methodology, and as measures of effect size mean difference and Hedge’s g, SRIs proved to be superior to drug placebo, with a modest effect size. From direct comparisons of CBT and SRI treatments, we conclude that CBT has the superior efficacy. COMBO versus CBT shows that SRI treatment adds little to concomitant CBT, while COMBO shows favourable outcome versus SRI alone. In pre-trial partial treatment responders, those who failed a SRI had better outcome from adding CBT as compared to continuing a SRI. Those who failed CBT treatment did as well with continued CBT as with switching to a SRI. The studies of combinations and sequences of treatments need to be developed further.

Bidragsytere

Tord Ivarsson

  • Tilknyttet:
    Forfatter
    ved RBUP Øst og Sør

Gudmundur Águst Skarphedinsson

  • Tilknyttet:
    Forfatter
    ved RBUP Øst og Sør
Aktiv cristin-person

Hege Kornør

  • Tilknyttet:
    Forfatter
    ved RBUP Øst og Sør

Brynhildur Axelsdottir

  • Tilknyttet:
    Forfatter
    ved RBUP Øst og Sør

Sølvi Biedilæ

  • Tilknyttet:
    Forfatter
    ved RBUP Øst og Sør
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