Cristin-resultat-ID: 1226048
Sist endret: 22. juni 2015 09:45
NVI-rapporteringsår: 2014
Resultat
Vitenskapelig artikkel
2015

Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maize

Bidragsytere:
  • Monica Andreassen
  • Elena Rocca
  • Thomas Bøhn
  • Odd Gunnar Wikmark
  • Johnnie van den Berg
  • Martinus Løvik
  • mfl.

Tidsskrift

Food and Agricultural Immunology
ISSN 0954-0105
e-ISSN 1465-3443
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2015
Publisert online: 2014
Volum: 26
Hefte: 4
Sider: 521 - 537
Open Access

Importkilder

Scopus-ID: 2-s2.0-84926516229

Klassifisering

Vitenskapsdisipliner

Medisinsk immunologi

Beskrivelse Beskrivelse

Tittel

Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maize

Sammendrag

Genetically modified (GM) crops may bring new proteins with immunogenic and allergenic properties into the food and feed chains. The most commonly grown GM maize, MON810, expresses a modified version of the insecticidal Cry1Ab protein originating in the soil bacterium Bacillus thuringiensis(Bt). Immune reactions following inhalation of pollen and debris from such plants have been scarcely studied. We exposed BALB/c mice to purified Cry1Ab proteins and Cry1Ab-containing MON810 plant materials by intranasal installation. No anti-Cry1Ab antibodies were detected following exposure to the plant materials. Exposure to purified Cry1Ab resulted in specific antiCry1Ab IgG1 and IgE production, indicating inherent immunogenicity and allergenicity. Mice exposed to leaf extracts from both MON810 and unmodified maize demonstrated influx of lymphocytes and eosinophils in the broncho-alveolar lavage, and increased cytokine release in mediastinal lymph node cells. The results indicate that the airway exposure to Cry1Ab proteins may be a route of practical relevance

Bidragsytere

Monica Andreassen

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved GenØk - Senter for biosikkerhet

Elena Rocca

  • Tilknyttet:
    Forfatter
    ved GenØk - Senter for biosikkerhet
Aktiv cristin-person

Thomas Bøhn

  • Tilknyttet:
    Forfatter
    ved Institutt for farmasi ved UiT Norges arktiske universitet
  • Tilknyttet:
    Forfatter
    ved GenØk - Senter for biosikkerhet

Odd Gunnar Wikmark

  • Tilknyttet:
    Forfatter
    ved GenØk - Senter for biosikkerhet

Johnnie van den Berg

  • Tilknyttet:
    Forfatter
    ved Noordwes-Universiteit
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