Cristin-resultat-ID: 1237164
Sist endret: 28. oktober 2016 16:37
NVI-rapporteringsår: 2015
Vitenskapelig artikkel

The total sale of prescription drugs with an abuse potential predicts the number of excessive users: a national prescription database study

  • Ingeborg Rossow og
  • Jørgen Gustav Bramness


BMC Public Health
ISSN 1471-2458
e-ISSN 1471-2458
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2015
Volum: 15:288
Artikkelnummer: 15:288
Open Access


Scopus-ID: 2-s2.0-84961364999

Beskrivelse Beskrivelse


The total sale of prescription drugs with an abuse potential predicts the number of excessive users: a national prescription database study


Prescription drug sales may vary considerably across regions and over time. This study aimed to assess whether there is an association between mean drug sales and prevalence of excessive use in a range of psychotropic prescription drugs with an abuse potential, and if so, whether the variation in mean drug sales mostly reflects variation in the prevalence of excessive use or mostly reflects variation in non-excessive use. Data on all filled prescriptions taken from the Norwegian prescription database for 10 drugs with an abuse potential (pain relievers, anxiolytics, and hypnotics) during one calendar year (2005) in Norway (n = 4 053 624) included number of defined daily doses (DDD). These were aggregated to individual level (n = 815 836) and county level (n = 19). Analyses of individual level data showed that the distribution of drug use was skewed; those who used more than 365 DDD per year accounted for almost half of the sales of both anxiolytics and hypnotics. At the county level, the mean sales per inhabitant and the prevalence of excessive users were closely correlated, but both prevalence of non-excessive use and prevalence of excessive drug use were associated with the county-wise variation in mean drug sales. Despite a strong individual control of access to psychotropic drugs through health personnel’ prescribing, a small proportion of users account for a large fraction of the sales of these drugs. The sales vary significantly between regions and this variation is closely associated with the prevalence of excessive users. This suggests that sales figures as such may be used as an indicator to monitor variations in excessive use between regions and over time, and to evaluate interventions targeting over-prescription and excessive use.


Aktiv cristin-person

Ingeborg Margrete Rossow

Bidragsyterens navn vises på dette resultatet som Ingeborg Rossow
  • Tilknyttet:
    ved Avdeling for rusmidler og tobakk ved Folkehelseinstituttet

Jørgen Gustav Bramness

  • Tilknyttet:
    ved Senter for Psykofarmakologi ved Diakonhjemmet sykehus
  • Tilknyttet:
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo
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