Cristin-resultat-ID: 1250666
Sist endret: 30. september 2015 11:31
NVI-rapporteringsår: 2015
Resultat
Vitenskapelig artikkel
2015

Vitamin B12 and folic acid improve gross motor and problem-solving skills in young North Indian children: A randomized placebo-controlled trial

Bidragsytere:
  • Ingrid Kvestad
  • Sunita Taneja
  • Tivendra Kumar
  • Mari Hysing
  • Helga Refsum
  • Chittaranjan S. Yajnik
  • mfl.

Tidsskrift

PLOS ONE
ISSN 1932-6203
e-ISSN 1932-6203
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2015
Volum: 10
Hefte: 6
Open Access

Importkilder

Scopus-ID: 2-s2.0-84939146548

Klassifisering

Vitenskapsdisipliner

Epidemiologi medisinsk og odontologisk statistikk

Beskrivelse Beskrivelse

Tittel

Vitamin B12 and folic acid improve gross motor and problem-solving skills in young North Indian children: A randomized placebo-controlled trial

Sammendrag

Objectives Deficiencies of vitamin B12 and folate are associated with delayed development and neurological manifestations. The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children. Methods In a randomized, double blind trial, children aged six to 30 months, received supplement with placebo or vitamin B12 and/or folic acid for six months. Children were allocated in a 1:1:1:1 ratio in a factorial design and in blocks of 16. We measured development in 422 children by the Ages and Stages Questionnaire 3rd ed. at the end of the intervention. Results Compared to placebo, children who received both vitamin B12 and folic acid had 0.45 (95% CI 0.19, 0.73) and 0.28 (95% CI 0.02, 0.54) higher SD-units in the domains of gross motor and problem solving functioning, respectively. The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study. With the exception of a significant improvement on gross motor scores by vitamin B12 alone, supplementation of either vitamin alone had no effect on any of the outcomes. Conclusion Our findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children. Trial Registration ClinicalTrials.gov NCT00717730

Bidragsytere

Ingrid Kvestad

  • Tilknyttet:
    Forfatter
    ved Institutt for biologisk og medisinsk psykologi ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Uni Research Helse - RKBU ved NORCE Norwegian Research Centre AS

Sunita Taneja

  • Tilknyttet:
    Forfatter
    ved Society for Applied Studies

Tivendra Kumar

  • Tilknyttet:
    Forfatter
    ved India

Mari Hysing

  • Tilknyttet:
    Forfatter
    ved Uni Research Helse - RKBU ved NORCE Norwegian Research Centre AS

Helga Margaretha Refsum

Bidragsyterens navn vises på dette resultatet som Helga Refsum
  • Tilknyttet:
    Forfatter
    ved Avdeling for ernæringsvitenskap ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved University of Oxford
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