Cristin-resultat-ID: 1252417
Sist endret: 27. november 2015, 13:10
NVI-rapporteringsår: 2015
Resultat
Vitenskapelig artikkel
2015

Intrauterine growth retardation in foetuses of women with epilepsy

Bidragsytere:
  • Anette Huuse Farmen
  • Jacob Holter Grundt
  • Torbjörn Tomson
  • Karl Otto Nakken
  • Ole Jakob Nakling
  • Petter Mowinckel
  • mfl.

Tidsskrift

Seizure
ISSN 1059-1311
e-ISSN 1532-2688
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2015
Volum: 28
Sider: 76 - 80

Importkilder

Scopus-ID: 2-s2.0-84929268526

Beskrivelse Beskrivelse

Tittel

Intrauterine growth retardation in foetuses of women with epilepsy

Sammendrag

Various factors may affect intrauterine foetal growth, amongst which conditions such as epilepsy and the use of anti-epileptic drugs (AED) may play a role. This study investigated intrauterine growth of foetuses in women with epilepsy, as compared with controls, and explored whether intrauterine growth was affected by prenatal exposure to AED. Method Data were obtained from prospectively registered data regarding pregnancy and prenatal and perinatal factors in women in Oppland County in Norway. The final analysis included information from 166 mothers with epilepsy and 287 children. The control group consisted of 40,553 pregnancies in women without epilepsy registered in the same database. Results There was a significantly higher risk of the ponderal index being below the 10th percentile and infants being small for gestational age (SGA) in the epilepsy group; exposure to AED increased the risk. The frequency of SGA and low ponderal index was highest in Lamotrigine exposed infants. In the AED group, head circumference was significantly smaller among Carbamazepine exposed. Conclusion Impaired intrauterine growth of foetuses in women with epilepsy was identified. The frequency of SGA and low ponderal index was highest in Lamotrigine exposed infants. The epilepsy group had a higher risk profile for having smaller babies, in being younger at age, lower in body weight and more frequent smokers. However despite these differences, the effects of epilepsy and AED exposure were significant. The ponderal index may be a useful supplement to more established measures assessing intrauterine growth in epilepsy.

Bidragsytere

Anette Huuse Farmen

  • Tilknyttet:
    Forfatter
    ved Div Gjøvik/Lillehammer ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Nevrologisk avdeling ved Oslo universitetssykehus HF

Jacob Holter Grundt

  • Tilknyttet:
    Forfatter
    ved Div Gjøvik/Lillehammer ved Sykehuset Innlandet HF

Torbjörn Tomson

  • Tilknyttet:
    Forfatter
    ved Karolinska Institutet

Karl Otto Nakken

  • Tilknyttet:
    Forfatter
    ved Spesialsykehus for epilepsi (SSE) ved Oslo universitetssykehus HF

Ole Jakob Nakling

  • Tilknyttet:
    Forfatter
    ved Div Gjøvik/Lillehammer ved Sykehuset Innlandet HF
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