Cristin-resultat-ID: 1290664
Sist endret: 14. september 2018, 09:48
NVI-rapporteringsår: 2015
Vitenskapelig artikkel

Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery

  • Ýrr Asbjørg Mørch
  • Rune Hansen
  • Sigrid Berg
  • Andreas Åslund
  • Wilhelm Glomm
  • Siv Eggen
  • mfl.


Contrast Media & Molecular Imaging
ISSN 1555-4309
e-ISSN 1555-4317
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2015
Volum: 10
Hefte: 5
Sider: 356 - 366
Open Access


Scopus-ID: 2-s2.0-84943587157

Beskrivelse Beskrivelse


Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery


Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology platform incorporating multiple functionalities, including imaging and therapy in a single system consisting of MBs stabilized by polyethylene glycol (PEG)-coated polymeric nanoparticles (NPs). The NPs, containing lipophilic drugs and/or contrast agents, are composed of the widely used poly(butyl cyanoacrylate) (PBCA) polymer and prepared in a single step. MBs stabilized by these NPs are subsequently prepared by self-assembly of NPs at the MB air–liquid interface. Here we show that these MBs can act as contrast agents for conventional ultrasound imaging. Successful encapsulation of iron oxide NPs inside the PBCA NPs is demonstrated, potentially enabling the NP–MBs to be used as magnetic resonance imaging (MRI) and/or molecular ultrasound imaging contrast agents. By precise tuning of the applied ultrasound pulse, the MBs burst and the NPs constituting the shell are released. This could result in increased local deposit of NPs into target tissue, providing improved therapy and imaging contrast compared with freely distributed NPs. Copyright © 2015 John Wiley & Sons, Ltd.


Ýrr Asbjørg Mørch

  • Tilknyttet:
    ved Bioteknologi og nanomedisin ved SINTEF AS

Rune Hansen

  • Tilknyttet:
    ved SINTEF Digital ved SINTEF AS

Sigrid Berg

  • Tilknyttet:
    ved Institutt for sirkulasjon og bildediagnostikk ved Norges teknisk-naturvitenskapelige universitet

Andreas Åslund

  • Tilknyttet:
    ved Institutt for fysikk ved Norges teknisk-naturvitenskapelige universitet

Wilhelm Robert Glomm

Bidragsyterens navn vises på dette resultatet som Wilhelm Glomm
  • Tilknyttet:
    ved Materialer og nanoteknologi ved SINTEF AS
  • Tilknyttet:
    ved Institutt for kjemisk prosessteknologi ved Norges teknisk-naturvitenskapelige universitet
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