Cristin-resultat-ID: 1314065
Sist endret: 18. juli 2016 14:21
NVI-rapporteringsår: 2015
Resultat
Vitenskapelig artikkel
2016

Cardiovascular risk estimation in older persons: SCORE O.P.

Bidragsytere:
  • Marie Therese Cooney
  • Randi Selmer
  • Anja Schou Lindman
  • Aage Tverdal
  • Alessandro Menotti
  • Troels Thomsen
  • mfl.

Tidsskrift

European Journal of Preventive Cardiology (EJPC)
ISSN 2047-4873
e-ISSN 2047-4881
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2016
Publisert online: 2015
Volum: 23
Hefte: 10
Sider: 1093 - 1103

Importkilder

Scopus-ID: 2-s2.0-84974623376

Klassifisering

Vitenskapsdisipliner

Medisinske fag

Emneord

Primærforebygging • Hjerte- og karsykdom • Eldre • Risikoestimering

HRCS

  • Helsekategori: 3 - Hjerte og kar
    Aktivitet: 4.4 - Befolkningsundersøkelser

Beskrivelse Beskrivelse

Tittel

Cardiovascular risk estimation in older persons: SCORE O.P.

Sammendrag

AIMS: Estimation of cardiovascular disease risk, using SCORE (Systematic COronary Risk Evaluation) is recommended by European guidelines on cardiovascular disease prevention. Risk estimation is inaccurate in older people. We hypothesized that this may be due to the assumption, inherent in current risk estimation systems, that risk factors function similarly in all age groups. We aimed to derive and validate a risk estimation function, SCORE O.P., solely from data from individuals aged 65 years and older. METHODS AND RESULTS: 20,704 men and 20,121 women, aged 65 and over and without pre-existing coronary disease, from four representative, prospective studies of the general population were included. These were Italian, Belgian and Danish studies (from original SCORE dataset) and the CONOR (Cohort of Norway) study. The variables which remained statistically significant in Cox proportional hazards model and were included in the SCORE O.P. model were: age, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, smoking status and diabetes. SCORE O.P. showed good discrimination; area under receiver operator characteristic curve (AUROC) 0.74 (95% confidence interval: 0.73 to 0.75). Calibration was also reasonable, Hosmer-Lemeshow goodness of fit test: 17.16 (men), 22.70 (women). Compared with the original SCORE function extrapolated to the ≥65 years age group discrimination improved, p = 0.05 (men), p 

Bidragsytere

Marie Therese Cooney

  • Tilknyttet:
    Forfatter
    ved The University of Dublin, Trinity College

Randi Marie Selmer

Bidragsyterens navn vises på dette resultatet som Randi Selmer
  • Tilknyttet:
    Forfatter
    ved Avdeling for kroniske sykdommer og aldring ved Folkehelseinstituttet

Anja Elsrud Schou Lindman

Bidragsyterens navn vises på dette resultatet som Anja Schou Lindman
  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Aage Tverdal

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet

Alessandro Menotti

  • Tilknyttet:
    Forfatter
    ved Italia
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