Sammendrag
Objectives: The aim of this study was to establish consensus for potential remission criteria for use in clinical trials of gout.
Methods: Experts (n=88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey® followed by a discrete choice experiment using 1000Minds®. The exercises focused on identifying domains, definitions for each domain and the timeframe over which remission should be defined.
Results: There were 49 respondents (56% response) to the initial survey with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%) and patient global assessment (93%) of disease activity as measurement domains in remission criteria. Consensus was also reached for domain definitions including serum urate (
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