Cristin-resultat-ID: 1381260
Sist endret: 14. september 2016 12:49
Resultat
Poster
2016

Smoking and risk of mucinous epithelial ovarian cancer among 300,000 women

Bidragsytere:
  • Idlir Licaj
  • Bjarne K. Jacobsen
  • Randi Selmer
  • Gertraud Maskarinec
  • Elisabete Weiderpass og
  • Inger Torhild Gram

Presentasjon

Navn på arrangementet: AACR 107th Annual Meeting 2016; April 16-20, 2016;
Sted: New Orleans, LA
Dato fra: 16. april 2016
Dato til: 20. april 2016

Arrangør:

Arrangørnavn: AACR

Om resultatet

Poster
Publiseringsår: 2016

Beskrivelse Beskrivelse

Tittel

Smoking and risk of mucinous epithelial ovarian cancer among 300,000 women

Sammendrag

Background In 2012, The International Agency for Research on Cancer classified mucinous epithelial ovarian cancer as tobacco related. In a recent pooled analysis of 51 epidemiological studies, smoking was associated with an increased risk of mucinous epithelial ovarian cancer, but not with other ovarian cancer histological subtypes. The main purpose of this study was to examine impact of smoking related increase in epithelial ovarian cancer according to histological subtypes and invasiveness in a large prospective cohort study. Methods We followed 300,398 Norwegian women born between 1899 and 1975, recruited from 1974 to 2003, by linkage to national virtually complete registries through December 2013. The three prospective cohort studies conducted by the Norwegian Institute of Public Health and included in the analysis were the Norwegian Counties Study (1974-1988), the 40 Years Study (1985-1999), and the Cohort of Norway (CONOR) Study (1994-2003). Their data were merged and analyzed altogether. We used Cox proportional hazard models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between smoking status, smoking-intensity and duration and epithelial ovarian cancer (EOC) histological subtypes. We used multivariable analyses stratified by birth cohort (≤1950>) and cohort study, and tested for heterogeneity by BMI, attained education and physical activity. Results During >5.9 million person-years, with a median follow-up of 19 years, 2,336 primary epithelial ovarian cancers (EOC) were identified, of which 1,647 (71%) invasive and 689 (29%) borderline. In our study, 38.0% of women were current, 21.1% former and 40.8% never smokers. Current versus never smokers risk of all histological subtypes of invasive EOC (multivariable HR = 0.97 95% CI, 0.86-1.08) was significantly different from the corresponding risk of all histological subtypes of borderline epithelial ovarian tumours (multivariate HR = 1.55 95% CI, 1.29-1.85) (pheterogeneity

Bidragsytere

Idlir Licaj

  • Tilknyttet:
    Forfatter
    ved Systems epidemiology, forskningsgruppe ved UiT Norges arktiske universitet

Bjarne Koster Jacobsen

Bidragsyterens navn vises på dette resultatet som Bjarne K. Jacobsen
  • Tilknyttet:
    Forfatter
    ved Kroniske sykdommers epidemiologi, forskningsgruppe ved UiT Norges arktiske universitet

Randi Marie Selmer

Bidragsyterens navn vises på dette resultatet som Randi Selmer
  • Tilknyttet:
    Forfatter
    ved Institutt for global helse og samfunnsmedisin ved Universitetet i Bergen

Gertraud Maskarinec

  • Tilknyttet:
    Forfatter

Elisabete Weiderpass

  • Tilknyttet:
    Forfatter
    ved Systems epidemiology, forskningsgruppe ved UiT Norges arktiske universitet
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