Cristin-resultat-ID: 1392618
Sist endret: 13. august 2019, 09:20
NVI-rapporteringsår: 2016
Resultat
Vitenskapelig artikkel
2016

Sweet taste pleasantness is modulated by morphine and naltrexone

Bidragsytere:
  • Marie Helene Eikemo
  • Guro Engvig Løseth
  • Tom Johnstone
  • Johannes Gjerstad
  • Frode Willoch og
  • Siri Leknes

Tidsskrift

Psychopharmacology
ISSN 0033-3158
e-ISSN 1432-2072
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2016
Volum: 233
Hefte: 21
Sider: 13711 - 3723

Importkilder

Scopus-ID: 2-s2.0-84982270118

Beskrivelse Beskrivelse

Tittel

Sweet taste pleasantness is modulated by morphine and naltrexone

Sammendrag

Background: Rodent models highlight the key role of μ-opioid receptor (MOR) signaling in palatable food consumption. In humans, however, the effects of MOR stimulation on eating and food liking remain unclear. Objectives Here, we tested sweet pleasantness experience in humans following MOR drug manipulations. We hypothesized that behaviors regulated by the endogenous MOR system would be enhanced by MOR agonism and decreased by antagonism. In line with rodent findings, we expected the strongest drug effects for the sweetest (high-calorie) sucrose stimuli. As very sweet stimuli are considered aversive by many people (called sweet dislikers), we also assessed whether MOR manipulations affect pleasantness ratings of sucrose-water stimuli differently depending on subjective and objective value. Methods: In a bidirectional psychopharmacological cross-over study, 49 healthy men underwent a sweet taste paradigm following double-blind administration of the MOR agonist morphine, placebo, and the opioid antagonist naltrexone. Results: As hypothesized, MOR stimulation with morphine increased pleasantness of the sweetest of five sucrose solutions, without enhancing pleasantness of the lower-sucrose solutions. For opioid antagonism, an opposite pattern was observed for the sweetest drink only. The observed drug effects on pleasantness of the sweetest drink did not differ between sweet likers and dislikers. Conclusions: The bidirectional effect of agonist and antagonist treatment aligns with rodent findings showing that MOR manipulations most strongly affect the highest-calorie foods. We speculate that the MOR system promotes survival in part by increasing concordance between the objective (caloric) and subjective (hedonic) value of food stimuli, so that feeding behavior becomes more focused on the richest food available.

Bidragsytere

Marie Eikemo

Bidragsyterens navn vises på dette resultatet som Marie Helene Eikemo
  • Tilknyttet:
    Forfatter
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Klinikk psykisk helse og avhengighet ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
    ved Psykologisk institutt ved Universitetet i Oslo

Guro Engvig Løseth

  • Tilknyttet:
    Forfatter
    ved Psykologisk institutt ved Universitetet i Oslo

Tom Johnstone

  • Tilknyttet:
    Forfatter
    ved University of Reading

Johannes Gjerstad

  • Tilknyttet:
    Forfatter
    ved Seksjon for fysiologi og cellebiologi ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Statens arbeidsmiljøinstitutt

Frode Willoch

  • Tilknyttet:
    Forfatter
    ved Nevrale systemer ved Universitetet i Oslo
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