Cristin-resultat-ID: 1408850
Sist endret: 27. februar 2017 13:41
NVI-rapporteringsår: 2016
Resultat
Vitenskapelig artikkel
2016

Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: A pooled analysis of three European birth cohorts

Bidragsytere:
  • Nina Iszatt
  • Hein Stigum
  • Eva Govarts
  • Lubica Palkovicova Murinova
  • Greet Schoeters
  • Tomas Trnovec
  • mfl.

Tidsskrift

Environment International
ISSN 0160-4120
e-ISSN 1873-6750
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2016
Volum: 94
Sider: 399 - 407
Open Access

Importkilder

Scopus-ID: 2-s2.0-84989339592

Beskrivelse Beskrivelse

Tittel

Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: A pooled analysis of three European birth cohorts

Sammendrag

Background: Dioxins and dioxin-like compounds are endocrine disrupting chemicals (EDCs). Experimental studies suggest perinatal exposure to EDCs results in later obesity. However, the few epidemiological investigations on dioxins are inconclusive. We investigated perinatal exposure to dioxins and dioxin-like compounds, infant growth and body mass index (BMI) in childhood. Methods: We pooled data from 3 European birth cohorts (Belgian, Norwegian, Slovak) with exposure assessment in cord blood or breast milk. Two cohorts had dioxin-like toxicity assessed using dioxin-responsive chemical activated luciferase expression (DR-CALUX) bioassay and one cohort had measured concentrations of dioxins, furans and dioxin-like polychlorinated biphenols with CALUX relative potency values applied. Growth was cohort- and sex-specific change in weight-for-age z-score between birth and 24 months (N = 367). BMI was calculated at around 7 years (median 7.17, interquartile range [IQR] 7.00-7.37 years, N = 251), and overweight defined according to international standards for children equivalent to adult BMI >25 kg/m(2) (Cole and Lobstein, 2012). We fitted multivariate models using generalized estimating equations, and tested effect modification by sex, breastfeeding and cohort. Results per 10 pg CALUX TEQ/g lipid increase in exposure. Results: Dioxin exposure was highest in the Belgian and lowest in the Norwegian cohort; median (IQR) of the pooled sample 13 (12.0) pg CALUX TEQ/g lipid. Perinatal exposure to dioxins and dioxin-like compounds appeared associated with increased growth between 0 and 24 months (adjusted estimate for change in z-score: beta = 0.07, 95% CI: -0.01, 0.14). At 7 years, dioxins exposure was associated with a statistically significant increase in BMI in girls (adjusted estimate for BMI units beta = 0.49, 95% CI: 0.07, 0.91) but not in boys (beta = -0.03, 95% CI: -0.55, 0.49) (p-interaction = 0.044). Furthermore, girls had a 54% (-6%, 151%) increased risk of overweight at 7 years (p-interaction = 0.023). Conclusion: Perinatal exposure to dioxin and dioxin-like compounds was associated with increased early infant growth, and increased BMI in school age girls. Studies in larger sample sizes are required to confirm these sex specific effects. (C) 2016 Elsevier Ltd. All rights reserved.

Bidragsytere

Aktiv cristin-person

Nina Louise Torcelino-Iszatt

Bidragsyterens navn vises på dette resultatet som Nina Iszatt
  • Tilknyttet:
    Forfatter
    ved Avdeling for miljøeksponering og -epidemiologi ved Folkehelseinstituttet
Aktiv cristin-person

Hein Stigum

  • Tilknyttet:
    Forfatter
    ved Avdeling for kroniske sykdommer og aldring ved Folkehelseinstituttet

Eva Govarts

  • Tilknyttet:
    Forfatter
    ved Vito

Lubica Palkovicova Murinova

  • Tilknyttet:
    Forfatter
    ved Slovenská zdravotnícka univerzita v Bratislave

Greet Schoeters

  • Tilknyttet:
    Forfatter
    ved Vito
  • Tilknyttet:
    Forfatter
    ved Universiteit Antwerpen
  • Tilknyttet:
    Forfatter
    ved Syddansk Universitet
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