Cristin-resultat-ID: 1425268
Sist endret: 11. oktober 2017, 14:27
NVI-rapporteringsår: 2016
Resultat
Vitenskapelig artikkel
2017

Serum osteoprotegrin (OPG) in subclinical atherosclerosis in systemic lupus erythematosus

Bidragsytere:
  • Adnan Kiani
  • Pål Aukrust
  • Thor Ueland
  • Ivana Hollan
  • Elizabeth L.M. Barr
  • Laurence S. Magder
  • mfl.

Tidsskrift

Lupus
ISSN 0961-2033
e-ISSN 1477-0962
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Publisert online: 2016
Volum: 26
Hefte: 8
Sider: 865 - 870

Importkilder

Scopus-ID: 2-s2.0-85020095531

Beskrivelse Beskrivelse

Tittel

Serum osteoprotegrin (OPG) in subclinical atherosclerosis in systemic lupus erythematosus

Sammendrag

INTRODUCTION: Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is strongly related to vascular calcification. We determined the association of this biomarker with subclinical atherosclerosis in systemic lupus erythematous (SLE). METHODS: We measured OPG and markers of subclinical atherosclerosis (coronary artery calcium (CAC), carotid intima-media thickness (cIMT) carotid plaque) in 166 SLE patients (91% female, 64% Caucasian, 31% African American, 5% others, mean age 45 years). Subgroups of patients with different levels of OPG level were compared with respect to average levels of CAC, cIMT, and with respect to presence of carotid plaque. Age was adjusted for using multiple regression. RESULTS: OPG was highly correlated with age (p 

Bidragsytere

Adnan Kiani

  • Tilknyttet:
    Forfatter
    ved The Johns Hopkins University

Pål Aukrust

  • Tilknyttet:
    Forfatter
    ved Avd. for revmatologi, hud og infeksjon ved Oslo universitetssykehus HF

Thor Ueland

  • Tilknyttet:
    Forfatter
    ved Institutt for indremedisinsk forskning (OUS) ved Oslo universitetssykehus HF

Ivana Hollan

  • Tilknyttet:
    Forfatter
    ved Revmatismesykehuset AS

Elizabeth L.M. Barr

  • Tilknyttet:
    Forfatter
    ved University of Maryland Baltimore
1 - 5 av 7 | Neste | Siste »