Cristin-resultat-ID: 1450717
Sist endret: 30. oktober 2017 11:19
NVI-rapporteringsår: 2016
Resultat
Vitenskapelig artikkel
2017

Accumulation of mineral oil saturated hydrocarbond (MOSH) in female Fisher 344 rats: comparison with human data and consequences for risk assessment

Bidragsytere:
  • Laura Barp
  • Maurus Biedermann
  • Koni Grob
  • Florence Blas-Y-Estrada
  • Unni Cecilie Nygaard
  • Jan Alexander
  • mfl.

Tidsskrift

Science of the Total Environment
ISSN 0048-9697
e-ISSN 1879-1026
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Publisert online: 2016
Volum: 575
Sider: 1263 - 1278

Importkilder

Scopus-ID: 2-s2.0-85000838030

Beskrivelse Beskrivelse

Tittel

Accumulation of mineral oil saturated hydrocarbond (MOSH) in female Fisher 344 rats: comparison with human data and consequences for risk assessment

Sammendrag

Female Fischer 344 rats were orally exposed to a mixture of mineral oil saturated hydrocarbons (MOSH) of broad molecular mass range at doses of 40, 400 and 4000mg/kg feed. Amounts and compositions of the MOSH were analyzed in liver, spleen, adipose tissue and the carcass after exposure during 30, 60, 90 and 120d as well as after 90d exposure followed by 30d depuration. At 40mg/kg in the feed, after 30d of exposure, 10.9% of the ingested MOSH were recovered from the animal body; after 90d plus 30d depuration it was 3.9%. In liver and spleen, the maximum retention in terms of molecular mass (simulated distillation) was at n-C29; in adipose tissue and carcass it was at n-C15/16. The differentiation between MOSH below and above n-C25 (Class I versus Class II and III oils), used for present regulation, is not supported by the present data on accumulation; structural characteristics seem more pertinent than molecular mass. Concentrations in the tissues increased far less than proportionally with the dose, rendering linear extrapolation to low doses questionable. No steady state was reached after 120d. In fact, comparing with the concentrations in human tissues at the estimated exposure, extrapolation from animal experiments seems to grossly underestimate human internal exposure. Comprehensive two-dimensional gas chromatography (GCxGC) was used to characterize the MOSH residues in the tissues with the aim of identifying the most strongly accumulated types. In the liver and spleen, the highly branched hydrocarbons dominated, whereas in the adipose tissue it was the n-alkanes and species with main n-alkyl moieties. Strong MOSH accumulation is not of concern per se, but the safety at the high concentrations in human tissues needs to be re-evaluated, possibly taking into account also end points other than granuloma formation.

Bidragsytere

Laura Barp

  • Tilknyttet:
    Forfatter
    ved Sveits

Maurus Biedermann

  • Tilknyttet:
    Forfatter
    ved Sveits

Koni Grob

  • Tilknyttet:
    Forfatter
    ved Sveits

Florence Blas-Y-Estrada

  • Tilknyttet:
    Forfatter
    ved Université Toulouse 1 Capitole

Unni Cecilie Nygaard

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet
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