Cristin-resultat-ID: 1459077
Sist endret: 27. september 2017 13:23
NVI-rapporteringsår: 2017
Resultat
Vitenskapelig artikkel
2017

Chronic alcohol overconsumption may alter gut microbial metabolism: a retrospective study of 719 13C-D-xylose breath test results

Bidragsytere:
  • Steinar Traae Bjørkhaug
  • Viggo Øystein Skar
  • Asle Wilhelm Medhus
  • Anita Tollisen
  • Jørgen Gustav Bramness og
  • Jørgen Valeur

Tidsskrift

Microbial Ecology in Health and Disease
ISSN 0891-060X
e-ISSN 1651-2235
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Publisert online: 2017
Volum: 28
Hefte: 1
Artikkelnummer: 1301725
Open Access

Beskrivelse Beskrivelse

Tittel

Chronic alcohol overconsumption may alter gut microbial metabolism: a retrospective study of 719 13C-D-xylose breath test results

Sammendrag

Objective: Alterations of gut microbiota composition or function may participate in the pathophysiology of several diseases. We aimed to explore the effect of chronic alcohol overconsumption on gut microbial metabolism, as assessed by evaluating 13C-D-xylose breath test results. Materials and methods: We investigated all 13C-D-xylose breath tests performed at Lovisenberg Diaconal Hospital during the years 2005 to 2011, using patient files for diagnosing the patients into one of three patient categories: alcohol overconsumption, coeliac disease and functional bowel disorder. In addition, a group of healthy controls was included. The time curves of 13CO2 excretion in breath samples were divided into two phases, evaluating small intestinal absorption (0–60 min) and colonic microbial metabolism (90–240 min), respectively. Results: A total of 719 patients underwent 13C-D-xylose breath testing during the inclusion period. Thirty-five had a history of alcohol overconsumption, 66 had coeliac disease, and 216 had a functional bowel disorder, while 44 healthy controls were included for comparison. The alcohol overconsumption group had similar small intestinal phase results as the group of patients with untreated coeliac disease. During the colonic phase, the group of patients with alcohol overconsumption differed from all the other groups in terms of 13C-xylose recovery, with significantly less 13CO2 excretion compared to the other groups. Conclusion: The results suggest that patients with a history of alcohol overconsumption suffer from both small intestinal malabsorption and impaired colonic microbial metabolism. The role of gut microbiota in chronic alcohol overconsumption should be investigated further.

Bidragsytere

Steinar Traae Bjørkhaug

  • Tilknyttet:
    Forfatter
    ved Unger-Vetlesens Forskningsinstitutt ved Lovisenberg Diakonale Sykehus

Viggo Øystein Skar

  • Tilknyttet:
    Forfatter
    ved Unger-Vetlesens Forskningsinstitutt ved Lovisenberg Diakonale Sykehus

Asle Wilhelm Medhus

  • Tilknyttet:
    Forfatter
    ved Gastromedisinsk avdeling ved Oslo universitetssykehus HF
Aktiv cristin-person

Anita Tollisen

  • Tilknyttet:
    Forfatter
    ved Unger-Vetlesens Forskningsinstitutt ved Lovisenberg Diakonale Sykehus

Jørgen Gustav Bramness

  • Tilknyttet:
    Forfatter
    ved Div Psykisk helsevern ved Sykehuset Innlandet HF
  • Tilknyttet:
    Forfatter
    ved Senter for rus- og avhengighetsforskning ved Universitetet i Oslo
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