Cristin-resultat-ID: 1467022
Sist endret: 18. oktober 2017 11:58
NVI-rapporteringsår: 2017
Resultat
Vitenskapelig artikkel
2017

Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children

Bidragsytere:
  • Ingrid Kvestad
  • Mari Hysing
  • Merina Shrestha
  • Manjeswori Ulak
  • Andrew L. Thorne-Lyman
  • Sigrun Henjum
  • mfl.

Tidsskrift

American Journal of Clinical Nutrition
ISSN 0002-9165
e-ISSN 1938-3207
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2017
Publisert online: 2017
Volum: 105
Hefte: 5
Sider: 1122 - 1131

Importkilder

Scopus-ID: 2-s2.0-85020894250

Finansiering

  • Norges forskningsråd

    • Prosjektkode: 223269
    • Prosjektkode: 234495

Beskrivelse Beskrivelse

Tittel

Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children

Sammendrag

Background: Poor vitamin B-12 (cobalamin) status is widespread in South Asia. Insufficient vitamin B-12 status has been linked to poor neurodevelopment in young children. Objective: We measured the associations between vitamin B-12 status in infancy (2–12 mo) and the development and cognitive functioning in Nepalese children 5 y later. Design: Vitamin B-12 status was assessed in infancy with the use of plasma cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA). At 5 y of age, we measured development with the use of the Ages and Stages Questionnaire, 3rd edition (ASQ-3), and cognitive functioning by using the Developmental Neuropsychological Assessment, 2nd edition (NEPSY II), in 320 children. In regression models, we estimated the associations between vitamin B-12 status, including a combined indicator of vitamin B-12 status (3cB12) and scores on the ASQ-3 and NEPSY II subtests. Results: All markers of vitamin B-12 status with the exception of plasma cobalamin were significantly associated with the total ASQ-3 scores in the multiple regression models. A 1-unit increase in the 3cB12 score was associated with an increase in the total ASQ-3 score of 4.88 (95% CI: 2.09, 7.68; P = 0.001). Increases in both plasma tHcy and MMA (indicating poorer status) were associated with a decrease in scores on the NEPSY II affect recognition and geometric puzzle subtests. Each unit increment in 3cB12 scores was associated with increases of 0.82 (95% CI: 0.49, 1.14; P

Bidragsytere

Ingrid Kvestad

  • Tilknyttet:
    Forfatter
    ved Uni Research Helse - RKBU ved NORCE Norwegian Research Centre AS

Mari Hysing

  • Tilknyttet:
    Forfatter
    ved Uni Research Helse - RKBU ved NORCE Norwegian Research Centre AS

Merina Shrestha

  • Tilknyttet:
    Forfatter
    ved Tribhuvan University

Manjeswori Ulak

  • Tilknyttet:
    Forfatter
    ved Tribhuvan University

Andrew L. Thorne-Lyman

  • Tilknyttet:
    Forfatter
    ved Harvard School of Public Health
  • Tilknyttet:
    Forfatter
    ved The Johns Hopkins University
  • Tilknyttet:
    Forfatter
    ved WorldFish Center
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