Cristin-resultat-ID: 1472256
Sist endret: 26. mai 2017, 22:51
Resultat
Fagbok
2017

Vitamin K2 and its Impact on Tooth Epigenetics

Bidragsytere:
  • Jan Oxholm Gordeladze
  • Maria Augusta Dos S Silva Landin
  • Gaute Floer Johnsen
  • Håvard Jostein Haugen og
  • Harald Osmundsen

Utgiver/serie

Utgiver

IntechOpen
NVI-nivå 1

Om resultatet

Fagbok
Publiseringsår: 2017
Antall sider: 27
ISBN: 978-953-51-3020-8
Revidert utgave

Klassifisering

Vitenskapsdisipliner

Molekylærbiologi

Emneord

Vitamin K2 • SXR • Endokrin • Deiodinases

Beskrivelse Beskrivelse

Tittel

Vitamin K2 and its Impact on Tooth Epigenetics

Sammendrag

The impact of nutritional signals plays an important role in systemic-based «models» of dental caries. Present hypotheses now focus both on the oral environment and other organs, like the nervous system and brain. The tooth is subjected to shear forces, nourishing and cleansing, and its present “support system” (the hypothalamus/parotid axis) relays endocrine signaling to the parotid gland. Sugar consumption enhances hypothalamic oxidative stress (ROS), reversing dentinal fluid flow, thus creating an enhanced vulnerability to the oral bacterial flora. The acid, produced by the oral bacterial flora, then leads to erosion of the dentine, and an irreversible loss of dental enamel layers. This attack brings about inflammatory responses, yielding metalloproteinase-based “dissolution”. However, vitamin K2 (i.e. MK-4/MK-7) may come to the rescue with its antioxidant property, locally (mouth cavity) or systemically (via the brain), thus sustaining/preserving hormone-induced dentinal fluid flow (encompassing oxidative stress) and boosting/magnifying bodily inflammatory responses. However, sugars may also reduce the tooth’s natural defences through endocrine signaling, thus enhancing acid-supported enamel dentine erosion. Vitamin K2 sustains and improves the salivary buffering capacity via its impact on the secretion/flow of calcium and inorganic phosphates. Interestingly, primitive cultures’ diets (low-sugar and high-K2 diets) preserve dental health.

Bidragsytere

Jan Oxholm Gordeladze

  • Tilknyttet:
    Forfatter
    ved Seksjon for Biokjemi ved Universitetet i Oslo
Aktiv cristin-person

Maria Landin

Bidragsyterens navn vises på dette resultatet som Maria Augusta Dos S Silva Landin
  • Tilknyttet:
    Forfatter
    ved Det odontologiske fakultet ved Universitetet i Oslo

Gaute Floer Johnsen

  • Tilknyttet:
    Forfatter
    ved Det odontologiske fakultet ved Universitetet i Oslo
Aktiv cristin-person

Håvard Jostein Haugen

  • Tilknyttet:
    Forfatter
    ved Biomaterialer ved Universitetet i Oslo
Inaktiv cristin-person

Harald Osmundsen

  • Tilknyttet:
    Forfatter
1 - 5 av 5

Kapitler/Artikler Kapitler/Artikler

Vitamin K2 in Animal Health: An Overview.

O'Neil, Jayde; Scarrott, Bethany; Svalheim, Ragnhild Aven; Elliot, Jonathan; Hodges, Stephen J.. 2017, IntechOpen. UIT, UNN, RVCUoL, NOFIMAVitenskapelig Kapittel/Artikkel/Konferanseartikkel
1 - 1 av 1